AI Article Synopsis
- Twenty-two 5-benzylidenethiazolidine-2,4-dione (TZD) derivatives were synthesized and tested for their effects on fat cell development in 3T3-L1 adipocytes, focusing on adiponectin protein levels.
- Among these derivatives, compound 3V showed promising results by increasing adiponectin expression and decreasing leptin secretion compared to the standard drug rosiglitazone at a concentration of 10 µM.
- In Wistar rats with non-alcoholic fatty liver disease induced by a high-fat diet, 3V administration led to reduced liver weight and visceral fat, along with improved blood biochemical markers, confirming its potential as a hepatoprotective agent.
Article Abstract
Twenty-two 5-benzylidenethiazolidine-2,4-dione derivatives (TZDs) were synthesized and evaluated for their potency on adipogenesis of 3T3-L1 adipocytes by measuring the expression of adiponectin protein. Among them, compared to rosiglitazone, 3V was found to upregulate the adiponectin protein expression and downregulate the secretion of leptin protein in 3T3-L1 adipocytes at a respective concentration of 10 µM. With respect to high-fat/high-calorie (HF/HC) diet-induced non-alcoholic fatty liver disease (NAFLD) in Wistar rats, oral administration of 3V could reduce liver weight, visceral fat, and improve serum levels of biochemical markers. H&E staining of liver sections validated 3V as a potent hepatoprotective agent for reducing fat deposition against NAFLD.
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| http://dx.doi.org/10.1002/ardp.201100413 | DOI Listing |
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