Predicting the progression of dementia is a challenge for clinicians yet this information is highly valued by patients' families. An informally observed 4-stage model of dementia can be helpful in educating caregivers and preparing them for what lies ahead. In the behavioral variant of frontotemporal dementia (bvFTD), this model describes the evolution of behavioral disturbances and is characterized by an inflection point between stage 2 (progressively severe behavioral aberration) and stage 3 (increasing apathy and remission of behavior problems). In this study, we sought evidence for this model using a database of serial Neuropsychiatric Inventory (NPI) scores for 45 patients with FTD and 47 patients with Alzheimer's disease (AD). We transformed the NPI scores into a single variable for each participant that represented the yearly rate of change in total NPI score and used this as the dependent variable in a multivariate linear regression. Age at onset of dementia, NPI score at initial visit, and duration of illness at first NPI all contributed significantly to the regression model in the bvFTD group. Participants with an initial NPI acquired before 6 years of disease duration tended to have a more positive rate of change in NPI total score (representing worsening behavioral disturbances) than those with an initial NPI performed after 6 years. None of the aforementioned variables were significantly associated with yearly change in NPI total score in the AD group. These results support a crescendo-decrescendo trajectory of behavioral symptoms in bvFTD but do not suggest that there is a similar pattern in AD, and further longitudinal data collection is necessary.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309273 | PMC |
| http://dx.doi.org/10.3233/JAD-2012-111916 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An updated network meta-analysis of non-pharmacological interventions for primary hypertension in adults: insights from recent studies.
Syst Rev
December 2024
Department of Acupuncture and Moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Background: Primary hypertension significantly impacts global cardiovascular health, contributing to increased mortality rates and posing a substantial public health challenge. Recognizing the growing evidence supporting non-pharmacological interventions (NPIs) for controlling primary hypertension, our study employs Network Meta-Analysis (NMA) to comprehensively assess their efficacy.
Methods: This review updates a prior systematic review by searching for original literature on NPIs for primary hypertension from 2013 to 2024.
A holistic approach to distribution, ecotoxicology, and human health risk of potentially hazardous emerging pollutants along the Egyptian Mediterranean coast: Univariate and multivariate analyses.
Mar Pollut Bull
December 2024
Department of Marine Ecology, Faculty of Aquaculture and Marine Fisheries, Arish University, Egypt. Electronic address:
This study examines pollution, ecotoxicological, and health risks of B, F, and S in seawater and sediments along the southern Mediterranean Sea. Strong positive loading on B in sediment, PLI, and NPI suggested that the high B content raises the total amount of contamination and cumulative risks to benthic organisms. Logk for S and F were <3 indicating that they were easily transported to the water column.
View Article and Find Full Text PDFEvaluating optic system compression in sellar tumors: A novel application of quantitative pupillometry.
Acta Neurochir (Wien)
December 2024
Medical Faculty of Heidelberg University, Heidelberg, Germany.
Introduction: Tumorous growths in the sellar region pose significant clinical challenges due to their proximity to critical visual structures such as the optic chiasm and optic nerves. Given their proximity to the optic system, these tumors are often diagnosed due to a progressive decrease in visual acuity. Thus, surgical intervention is crucial to prevent irreversible damage, as timely decompression can halt the progression of edema and subsequent optic atrophy.
View Article and Find Full Text PDFDiagnostic abnormalities, disease severity and immunotherapy responsiveness in individuals with Down syndrome regression disorder.
Sci Rep
December 2024
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Introduction: Down Syndrome Regression Disorder (DSRD) is a neuropsychiatric condition causing insomnia, catatonia, encephalopathy, and obsessive-compulsive behavior in otherwise healthy individuals with Down syndrome (DS). Smaller cohorts have identified heterogenous diagnostic abnormalities which have predicted immunotherapy responsiveness although pattern analysis in a large cohort has never been performed.
Methods: A multi-center, retrospective study of individuals with DSRD was performed.
Implementation of Function Focused Care for Acute Care Using the Evidence Integration Triangle.
J Am Geriatr Soc
December 2024
Chair of the Department of Organizational Systems and Health, University of Maryland Medical Center, University of Maryland School of Nursing, Baltimore, Maryland, USA.
Background: The purpose of this study was to test the impact of Function Focused Care for Acute Care Using the Evidence Integration Triangle (FFC-AC-EIT) on hospitalized patients living with dementia.
Methods: This was a clustered randomized clinical trial including 12 hospitals from two states and 455 patients living with dementia. Hospitals were randomized to FFC-AC-EIT versus FFC Education Only.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!