AI Article Synopsis
- Thirty 2,4,6-trichlorophenylhydrazine Schiff bases were synthesized and tested for their ability to scavenge DPPH radicals and superoxide anions.
- The compounds exhibited a wide range of DPPH scavenging activity with IC50 values from 4.05 to 369.30 µM, where several compounds notably outperformed the standard n-propylgallate.
- For superoxide anion scavenging, IC50 values ranged from 91.23 to 406.90 µM, with specific compounds again demonstrating better performance than the standard n-propylgallate.
Article Abstract
Syntheses of thirty 2,4,6-trichlorophenylhydrazine Schiff bases 1-30 were carried out and evaluated for their in vitro DPPH radical and super oxide anion scavenging activities. Compounds 1-30 have shown a varying degree of DPPH radical scavenging activity and their IC50 values range between 4.05-369.30 µM. The compounds 17, 28, 18, 14, 8, 15, 12, 2, 29, and 7 exhibited IC50 values ranging between 4.05±0.06-24.42±0.86 µM which are superior to standard n-propylgallate (IC50=30.12±0.27 µM). Selected compounds have shown a varying degree of superoxide anion radical scavenger activity and their IC50 values range between 91.23-406.90 µM. The compounds 28, 8, 17, 15, and 14, showed IC50 values between 91.23±1.2-105.31±2.29 µM which are superior to standard n-propylgallate (IC50=106.34±1.6 µM).
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| http://dx.doi.org/10.2174/1573406411208030452 | DOI Listing |
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