Animal models.

Methods Mol Biol

Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.

Published: August 2012

AI Article Synopsis

  • The text discusses five established animal models used in influenza research, highlighting their similarities and differences.
  • Although they share commonalities like virus types and handling conditions, each model has unique practical applications that are important for specific scientific questions.
  • There is no one-size-fits-all animal model for influenza; the choice of model and experimental conditions should align with the research question being pursued.

Article Abstract

Five well-established animal models in influenza research are discussed in a schematic fashion. Although there are clear parallels between these models, like viruses used, housing and handling conditions under biosafety conditions, routes of virus inoculation, sampling strategies, and necropsy techniques (mostly elaborated on in Subheading 4), each of these models involves specific differences in their practical applicability that need thorough assessment depending on the scientific question raised. In other words, there is no universal animal model for influenza and depending on the actual question to be answered the model and the experimental conditions should be carefully selected.

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http://dx.doi.org/10.1007/978-1-61779-621-0_8DOI Listing

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