AI Article Synopsis
- The study assessed the developmental potential of various cumulus cell-oocyte complexes (COCs) derived from in vitro maturation (IVM) cycles.
- Significant differences were found in pregnancy and implantation rates among COC categories, with expanded cumulus mass enclosing a mature oocyte (EC-MII) showing the best results.
- FSH/HCG priming improved the developmental competence of oocytes, while natural cycles or HCG alone resulted in lower outcomes.
Article Abstract
Purpose: To assess retrospectively the developmental potential of different types of cumulus cell-oocyte complexes (COCs) derived from IVM cycles.
Methods: IVM cycles were performed in natural cycles or after HCG, FSH, or FSH/HCG priming. COCs recovered were morphologically characterized in different types: compact (CC) or expanded (EC) cumulus mass but including an immature oocyte, and expanded cumulus mass enclosing a mature oocyte (EC-MII). Embryo developmental competence was investigated analysing exclusively cycles in which all transferred embryos derived from the same COC category.
Results: Fertilization rates did not differ significantly. Significant differences in pregnancy rates (14.5%, 10.0% and 27.6 % in the CC, EC, and EC-MII categories, respectively) were observed. Likewise, significant differences in implantation rates (8.9%, 6.3% and 19.1% in the CC, EC, and EC-MII categories, respectively) were found. Overall, priming with FSH/HCG had a beneficial effect on pregnancy and implantation rates, while no priming or HCG alone generated oocytes with poor competence.
Conclusions: In IVM cycles, morphological evaluation at the time of collection can predict the developmental ability of different COCs. FSH/HGC priming has a positive effect on oocyte competence.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370039 | PMC |
| http://dx.doi.org/10.1007/s10815-012-9766-2 | DOI Listing |
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