AI Article Synopsis
- The paper introduces a model for erythropoiesis based on the assumption that iron availability is adequate, with ongoing research focusing on iron dynamics.
- The model successfully predicts scenarios like red blood cell recovery post-blood donation and adaptation to high altitudes.
- It highlights how optimizing administration regimens of erythropoiesis-stimulating agents, such as Epoetin-α, can significantly reduce drug dosage while effectively managing red blood cell production, incorporating the concept of neocytolysis.
Article Abstract
In this paper we present a model for erythropoiesis under the basic assumption that sufficient iron availability is guaranteed. An extension of the model including a sub-model for the iron dynamics in the body is topic of present research efforts. The model gives excellent results for a number of important situations: recovery of the red blood cell mass after blood donation, adaptation of the number of red blood cells to changes in the altitude of residence and, most important, the reaction of the body to different administration regimens of erythropoiesis stimulating agents, as for instance in the case of pre-surgical administration of Epoetin-α. The simulation results concerning the last item show that choosing an appropriate administration regimen can reduce the total amount of the administered drug considerably. The core of the model consists of structured population equations for the different cell populations which are considered. A key feature of the model is the incorporation of neocytolysis.
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| http://dx.doi.org/10.1007/s00285-012-0530-0 | DOI Listing |
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