Purpose: The aim of this study was a prospective evaluation of new algorithms for the treatment of presbyopia using a light-adjustable intraocular lens (LAL).
Patients And Methods: A total of 15 patients scheduled for routine cataract surgery were included in the study. Following cataract removal a LAL (CalhounVision, Pasadena, CA) was implanted. At approximately 2 weeks after implantation the IOL was adjusted to correct any residual refractive error (sphere and cylinder) followed by the creation of a customized near add (CNA) that was based on the individual patient pupil size in one eye. The fellow eye was corrected for emmetropia. A final lock-in treatment was then performed.
Results: There were no complications observed during the surgery or power adjustments. All patients demonstrated an improvement in near vision (0.97 ± 0.18) and distance vision (0.78 ± 0.18) with good intermediate vision (0.92 ± 0.12) months after the final lock-in.
Conclusion: This preliminary study showed that the creation of a CNA based on the individual patient's pupil size, provided patients with a good range of near, intermediate and distance vision following implantation of the LAL.
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http://dx.doi.org/10.1007/s00347-012-2557-4 | DOI Listing |
Genome Res
January 2025
University Medical Center Utrecht, Utrecht University, Oncode Institute, Cyclomics
Shallow genome-wide cell-free DNA (cfDNA) sequencing holds great promise for non-invasive cancer monitoring by providing reliable copy number alteration (CNA) and fragmentomic profiles. Single nucleotide variations (SNVs) are, however, much harder to identify with low sequencing depth due to sequencing errors. Here we present Nanopore Rolling Circle Amplification (RCA)-enhanced Consensus Sequencing (NanoRCS), which leverages RCA and consensus calling based on genome-wide long-read nanopore sequencing to enable simultaneous multimodal tumor fraction estimation through SNVs, CNAs, and fragmentomics.
View Article and Find Full Text PDFSmall
January 2025
Department of Chemical Engineering, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, 247667, India.
Growing global population, escalating energy consumption, and climate change threaten future energy security. Fossil fuel combustion, primarily coal, oil, and natural gas, exacerbates the greenhouse effect driving global warming through CO emissions. To address such issues, research is focused on converting CO into valuable fuels and chemicals, which aims to reduce noxious CO and simultaneously bridge the gap between energy demands and sustainable supply.
View Article and Find Full Text PDFRes Involv Engagem
December 2024
Rotman Research Institute, Baycrest Academy for Research and Education, 3560 Bathurst Street, Toronto, ON, M6A 2E1, Canada.
Background: Collaborative research with end-users is an effective way to generate meaningful research applications and support greater impact on practice and knowledge exchange. To address these needs, a Citizen Advisory Group (CAG) of nine older adults (ages 64-80, 67% women) was formed to advise scientists on the development of Brain Health PRO (BHPro), a web-based platform designed to increase dementia prevention literacy and awareness. The current study evaluated if the CAG met its objectives, how inclusion of the CAG aligned with collaborative research approaches, and the CAG's experience and satisfaction throughout the development process.
View Article and Find Full Text PDFPrev Chronic Dis
December 2024
Community Impact Office, Markey Cancer Center, University of Kentucky, Lexington.
Introduction: Kentucky has the highest all-site cancer incidence and death rate in the US. In 2021, the University of Kentucky Markey Cancer Center convened a steering committee to conduct a statewide community cancer needs assessment (CNA). The goal of the final CNA phase was to gather community input on prioritizing Kentucky's cancer-related needs and ways to address them.
View Article and Find Full Text PDFPhys Chem Chem Phys
December 2024
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Metal cluster fullerenes are a class of molecular nanomaterials with complex structures and novel properties. An in-depth study of their formation mechanism is a key topic for developing new high-yield synthesis methods and promoting the practical application of such molecular nanomaterials. To elucidate the formation mechanism of ScN@C, a representative sub-class of metal cluster fullerenes, this study developed a ReaxFF force field parameter set CNSc.
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