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Identification of a novel specific small-molecule melanocortin-2-receptor antagonist.
Endocr Connect
December 2022
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
The overproduction of adrenocorticotropic hormone (ACTH), in conditions such as Cushing's disease and congenital adrenal hyperplasia (CAH), leads to significant morbidity. Current treatment with glucocorticoids does not adequately suppress plasma ACTH, resulting in excess adrenal androgen production. At present, there is no effective medical treatment in clinical use that would directly block the action of ACTH.
View Article and Find Full Text PDFMagnesium enhances cardiomyocyte proliferation and suppresses cardiac fibrosis induced by chronic ACTH exposure in rats.
Magnes Res
May 2021
Department of Physiology, University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11121 Belgrade, Serbia.
Chronic stress has been implicated in the development and progression of heart disease. In the past decade, a link between chronic stress and cardiac fibrosis has been described. Here, we focused on investigating the effects of one of the key molecular effectors of the stress response-adrenocorticotropic hormone (ACTH) on cardiac histopathology.
View Article and Find Full Text PDFProduction of 11-Oxygenated Androgens by Testicular Adrenal Rest Tumors.
J Clin Endocrinol Metab
January 2022
Department of Pediatrics, Radboud Amalia Children's Hospital, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Context: Testicular adrenal rest tumors (TART) are a common complication in males with classic 21-hydroxylase deficiency (21OHD). TART are likely to contribute to the androgen excess in 21OHD patients, but a direct quantification of steroidogenesis from these tumors has not been yet done.
Objective: We aimed to define the production of 11-oxygenated 19-carbon (11oxC19) steroids by TART.
Metformin inhibits the activation of melanocortin receptors 2 and 3 in vitro: A possible mechanism for its anti-androgenic and weight balancing effects in vivo?
J Steroid Biochem Mol Biol
June 2020
Pediatric Endocrinology, Diabetology, and Metabolism, Department of Pediatrics, University Children's Hospital Bern, 3010, Bern, Switzerland; Department of Biomedical Research, University of Bern, 3010, Bern, Switzerland. Electronic address:
Metformin is recommended as one of the first-line drugs for the treatment of type 2 diabetes and the metabolic syndrome. In addition to its insulin sensitizing effects, it has been shown to attenuate androgen excess in women with polycystic ovary syndrome (PCOS) or congenital adrenal hyperplasia (CAH), as well as to ameliorate obesity. The mechanisms of metformin action seem manifold.
View Article and Find Full Text PDFEffect of retinoic acid on human adrenal corticosteroid synthesis.
Life Sci
April 2016
Neuroendocrinology Research Laboratory, Istituto Auxologico Italiano, IRCCS, Cusano Milanino, MI, Italy; Department of Clinical Sciences & Community Health, University of Milan, Milan, Italy. Electronic address:
Aims: Retinoic acid has recently yielded promising results in the treatment of Cushing's disease, i.e., excess cortisol secretion due to a pituitary corticotropin (ACTH)-secreting adenoma.
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