Background: The symptoms of mad honey poisoning resemble those of cholinergic toxidromes; however, it is not clear whether they share a common biochemical basis.
Objectives: The aim of this study was to investigate a possible resemblance between mad honey poisoning and cholinergic toxidromes.
Methods: This is a descriptive study performed prospectively in patients presenting to a University Medical Faculty Emergency Medicine Department emergency service with mad honey poisoning over 1 year, from September 2008 to September 2009. Adult patients with clinical findings suggesting mad honey poisoning (i.e., bradycardia, hypotension, syncope, and vertigo) and with a history of honey consumption were enrolled. Pseudocholinesterase levels in blood samples taken from the mad honey-poisoned patients were analyzed to determine whether these were lower than normal pseudocholinesterase levels for adults (5400-13,200 U/L).
Results: The most common symptoms of the 30 patients enrolled in the study were vertigo and nausea. Low blood pressure and bradycardia were the most frequently observed physical examination findings. None of the patients enrolled had a history of disease that might cause low pseudocholinesterase. Mean pseudocholinesterase levels in our patients with mad honey poisoning were 7139.30 ± 2316.41 U/L (min-max: 1785-12,835). Blood pseudocholinesterase levels were within normal limits in 90% of patients and below normal in 10%.
Conclusion: A low pseudocholinesterase level was found in 3 (10%) of our 30 patients. These biochemical data do not support the hypothesis that mad honey poisoning should be regarded as cholinergic poisoning.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jemermed.2011.08.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Article Synopsis
- Aged honey may contain grayanotoxins, which can interact negatively with alcohol.
- Combining these substances can worsen symptoms like fainting (syncope) and low blood pressure (hypotension).
- Elderly patients with existing health issues need to be especially cautious and have their situations evaluated carefully.
Mad honey (wild honey) poisoning: clinical case series from Nepal.
Ann Med Surg (Lond)
September 2024
Metro Kathmandu Hospital, Maharajgunj, Kathmandu.
Introduction: Mad honey is commonly used for hypertension, and coronary artery disease, and as a sexual stimulant. Patients with mad honey poisoning present with dizziness, nausea, syncope, blurred vision, bradycardia, and hypotension with ECG findings of sinus bradycardia, complete AV block, and ST elevation.
Case Discussion: Here, the authors report five cases admitted to our tertiary care center following the consumption of mad honey.
Mad Honey Ingestion Leading to Grayanotoxin Poisoning During the Burning Man Music Festival: A Case Series.
Cureus
June 2024
Medical Toxicology, Maimonides Medical Center, Brooklyn, USA.
This is a case series of three patients who presented to the medical facilities at Burning Man, an annual week-long gathering in the Black Rock Desert of Nevada, for recreational grayanotoxin ingestion. Grayanotoxin, also known as "mad honey," caused the patients to present with varying degrees of dizziness, nausea, vomiting, and diarrhea based on the quantity ingested. Vital signs showed significant bradycardia and hypotension and were successfully treated with atropine and intravenous fluids.
View Article and Find Full Text PDFThe relationship between oxidative stress and apoptosis of histopathological changes in the ovary made by mad honey containing grayanotoxin.
Food Chem Toxicol
May 2024
Department of Emergency Medicine, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Article Synopsis
- This study looked at how mad honey affects the ovaries of female rats, focusing on cell death and a molecule called nitric oxide.
- The researchers had three groups of rats: one group got mad honey, another got normal honey, and the third group was a control with no honey.
- Results showed that mad honey led to more cell death in the ovaries compared to normal honey, suggesting it might harm the ovarian follicles.
Anaphylactic shock following the mad honey consumption: a case report.
Ann Med Surg (Lond)
February 2024
KIST Medical College, Lalitpur, Imadole.
Article Synopsis
- Mad honey, which comes from rhododendron plants in Nepal, can make people very sick because it contains special toxins called grayanotoxins that affect the heart and stomach.
- A 51-year-old woman had a serious reaction called anaphylactic shock after eating mad honey, showing symptoms like nausea and swelling, but she was not previously allergic to honey.
- Doctors need to be aware of the dangers of mad honey and act quickly if someone feels strange after eating it, especially in areas where it is commonly used.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!