AI Article Synopsis
- The study focuses on the link between p53 gene variations and breast cancer risk in South Indian women.
- Genotyping of 100 women (50 with breast cancer and 50 controls) examined specific p53 polylorphisms and mutations.
- Findings revealed no significant association between the p53 variants and breast cancer risk, although mutations in exon 7 codon 249 were more common in patients, particularly among those exposed to pollution.
Article Abstract
Background: We investigated the association between polymorphisms in the p53 tumor suppressor gene and breast cancer risk in women especially in the Southern part of India.
Methods: Genotyping was performed for 50 breast cancer women and 50 controls to determine the status of p53 exon 4 codon 72 polymorphism and exon 7 codon 249 mutation and their possible role in breast cancer risk.
Results: Frequency of Arg/Arg at codon 72 was 18% in controls and 28% in patients, Arg/Pro frequency was 56% and 66%, Pro/Pro genotype was 8% in controls and 8% in patients. No significance was observed for breast cancer risk with either Arg/Arg or Pro/Pro genotype in codon 72 polymorphism. Similarly, mutation analysis of exon 7 codon 249 revealed that 72% of breast cancer patients have mutation, which is not statistically significant. However, there is a strong association between increase in exon 7 codon 249 mutation and exposure to pollution.
Conclusion: The results suggested that there is no risk for exon 4 with Arg/Arg or Pro/Pro polymorphisms in the p53 gene and there is no strong correlation between breast cancer patients and mutation in exon 7 codon 249 in South Indian women.
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| http://dx.doi.org/10.7314/apjcp.2012.13.2.511 | DOI Listing |
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