AI Article Synopsis
- The study aimed to assess the feasibility of a contingent test for Down's syndrome screening in early pregnancy, focusing on its sensitivity and false positive rate.
- A total of 10,452 pregnant women participated, with the contingent test identifying an intermediate risk group, resulting in a sensitivity of 70.8% and a false positive rate of 2%.
- Ultimately, while the contingent test lowered the false positive rate, its sensitivity was deemed insufficient for effective Down's syndrome screening.
Article Abstract
Objectives: To evaluate the possibility of implementing a contingent test as a screening method for Down's syndrome (DS) in the first trimester of pregnancy, and assess its sensitivity (Sen) and false positive rate (FPR).
Methods: Prospective study covering a 4-year study period (July 2006-June 2010). Pregnant women were offered a combined test (CT) as the first step of a contingent test. An intermediate risk group is identified in the CT (1/101 and 1/1000) and offered an ultrasound assessment of secondary s (nasal bone, ductus venosus, tricuspid regurgitation).
Results: CTs were performed on 10,452 pregnant women (24 cases of DS). In the intermediate risk group, which had 7 cases of DS, we performed secondary ultrasound marker assessment on 98.1% (1,017/1,036). The CT and the contingent test had a Sen of 83% (95% CI; 67.9-98) (20/24) and 70.8% (95% CI; 52.6-88.9) (17/24) with an FPR of 3% (95% CI; 2.7-3.3) (316/10,430) and 2% (95% CI; 1.7-2.3) (220/10,408), respectively.
Conclusions: With the contingent test, we managed to reduce the FPR, but the Sen was too low for use as a screening method for DS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/14767058.2012.684168 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Atomistic Study on the Mechanical Properties of HOP-Graphene Under Variable Strain, Temperature, and Defect Conditions.
Nanomaterials (Basel)
December 2024
Institute of Manufacturing Engineering, Huaqiao University, Xiamen 361021, China.
HOP-graphene is a graphene structural derivative consisting of 5-, 6-, and 8-membered carbon rings with distinctive electrical properties. This paper presents a systematic investigation of the effects of varying sizes, strain rates, temperatures, and defects on the mechanical properties of HOP-graphene, utilizing molecular dynamics simulations. The results revealed that Young's modulus of HOP-graphene in the armchair direction is 21.
View Article and Find Full Text PDFUsing a Group Stimulus Preference Assessment to Design an Effective Group Contingency.
Behav Anal Pract
December 2024
University of Kentucky, Lexington, KY USA.
Unlabelled: The purpose of this study was to extend the limited research on group stimulus preference assessment (SPA) procedures. The study occurred in two sections of a middle school special education classroom and included 20 students with multi-categorical disabilities. A paired stimulus group SPA was used to identify a preference hierarchy for each class, and results were validated using single case designs in which baseline conditions were compared to group contingency conditions with alternating sessions of the highest-preferred (high-p) and lowest-preferred (low-p) consequences.
View Article and Find Full Text PDFOptical Phonon Decay and Improved Thermoelectric Efficiency in p-Type MgSb.
ACS Appl Mater Interfaces
January 2025
International Advanced Research Centre for Powder Metallurgy and New Materials (ARCI), IIT M Research Park, Chennai 600113, India.
The MgSb-based layered compounds exhibit exceptional thermoelectric properties over a wide temperature range and possess the potential to supplant traditional BiTe modules with reliable and economical MgSb-based thermoelectric devices, contingent upon the availability of a complementary p-type MgSb material with high thermoelectric efficiency comparable to that of n-type MgSb. We provide a simpler method involving the codoping of monovalent atoms (K and Na) at the Mg site of the MgSb lattice to improve the thermoelectric performance of p-type MgSb. K-Na codoping results in a peak power factor of around 0.
View Article and Find Full Text PDFResearch suggests that teams can greatly enhance their performance through boundary management, which comprises activities that establish, maintain, and regulate linkages with the surrounding environment. However, such performance gains do not materialize equally in all instances, and some teams struggle to benefit from boundary management. Integrating insights from social network and team-level resource allocation theories, we develop a contingency framework that considers the internal organization of a team's boundary management (i.
View Article and Find Full Text PDFNational Telehealth Contingency Staffing Program and Primary Care Quality in the VHA.
JAMA Netw Open
January 2025
Center for Veteran-Centered and Value-Driven Care, Puget Sound VA Healthcare System, Seattle, Washington.
Importance: The Veterans Health Administration (VHA) launched the Clinical Resource Hub (CRH), a national telehealth contingency staffing program, to address primary care staffing shortages and improve veteran access to primary care. How this large-scale telehealth intervention affects quality of care is unknown.
Objective: To assess the quality of care for chronic disease management among US veterans receiving high vs low levels of CRH-delivered primary care services and whether racial and ethnic minority veterans experience outcomes similar to those of White veterans when receiving CRH-delivered care.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!