AI Article Synopsis
- Hydroxyapatite (HAP) is a biocompatible bone-like compound, but it lacks the ability to induce bone formation on its own.
- This study explored a modified version called nano-Sr-HAP, which replaces some calcium in HAP with strontium, enhancing its potential as a bone-forming agent.
- Results showed that nano-Sr-HAP improved the growth and mineralization of bone cells compared to regular nano-HAP, suggesting it could be effective for treating osteoporosis-related bone defects.
Article Abstract
Hydroxyapatite (HAP), a CaP compound similar to the mineral phase present in bone, has excellent biocompatibility but little osseous inductivity. In this study, we evaluated the novel nano-Sr-HAP, in which the calcium of hydroxyapatite was substituted with strontium, which acts as a bone-forming agent. Its biocompatibility and osteoinduction were assayed using marrow mesenchymal stem cells (MSCs) and osteoblasts (OBs) in vitro. We were able to demonstrate that nano-Sr-HAP supported increased OB cell adhesion, proliferation and viability up to 4 days in culture when compared with nano-HAP. MSCs cultured with nano-Sr-HAP showed higher alkaline phosphatase (ALP) activity. More extracellular mineralized nodules were found with nano-Sr-HAP compared to nano-HAP, especially in images of ALP staining. We suggest that nano-Sr-HAP powders possess osteoconductive and osteoinductive properties and have the potential to be used in the repair of bone defects caused by osteoporotic fractures.
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| http://dx.doi.org/10.1166/jnn.2012.5125 | DOI Listing |
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