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Polymorphisms Influence the Expression of the Fas and FasL Genes in COVID-19.
Int J Mol Sci
January 2025
Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém 66075-110, Brazil.
The apoptotic molecule Fas and its ligand FasL are involved in the process of T-lymphocyte death, which may lead to lymphopenia, a characteristic of severe coronavirus disease 2019 (COVID-19). In this study, we investigated the influence of polymorphisms in the and genes, and gene expression, and plasma cytokine levels on COVID-19 severity and long COVID occurrence. A total of 116 individuals with severe COVID-19 and 254 with the non-severe form of the disease were evaluated.
View Article and Find Full Text PDFElevated uric acid levels, mortality and cognitive impairment in children with severe malaria.
Nat Med
January 2025
Ryan White Center for Pediatric Infectious Diseases and Global Health, Indiana University School of Medicine, Indianapolis, IN, USA.
We investigated the role of uric acid in the pathogenesis of severe malaria (SM) in two independent cohorts of children with SM. Hyperuricemia (blood uric acid ≥ 7 mg dl) was present in 25% of children with SM and was associated with increased in-hospital mortality and postdischarge mortality in both cohorts. Increased blood uric acid levels were also associated with worse scores in overall cognition in children with SM < 5 years old in both cohorts.
View Article and Find Full Text PDFRandomised feasibility study of an intestinal adsorbent in acute diarrhoea in The Gambia.
BMJ Paediatr Open
January 2025
Department of Paediatrics, Edward Francis Small Teaching Hospital, Banjul, Gambia
Background: Diarrhoea remains a leading cause of death in children. An intestinal adsorbent may reduce diarrhoea duration and severity.
Methods: Randomised controlled feasibility trial with two phases: phase 1 (0-4 hours and double-blind) and phase 2 (up to 5 days and open-label).
Severe knowlesi malaria with acute neurocognitive impairment: A case report.
IJID Reg
March 2025
Division of Infectious Disease and Tropical Medicine, Department of Internal Medicine, Abdoel Wahab Sjahranie General Hospital/Mulawarman University Faculty of Medicine, Samarinda, Indonesia.
infection in Indonesia has been reported from Sumatera and Kalimantan Island. has the shortest asexual replication cycle of all species, leading to rapidly increased parasitemia levels; however, it usually does not cause high parasitemia. It was reported a severe knowlesi malaria case in a 41-year-old male patient in Samarinda, East Kalimantan Province, Indonesia.
View Article and Find Full Text PDFA Rare Case of Locally Acquired Malaria in Lebanon: A Public Health Concern.
Cureus
December 2024
Clinical Pathology and Laboratory Department, Bekaa Hospital, Bekaa, LBN.
Malaria, a mosquito-borne disease caused by five plasmodium species, still has a life-threatening risk worldwide. Clinical manifestations can range from mild nonspecific symptoms to severe disease. In non-endemic regions, sporadic cases frequently pose significant challenges to health workers as delayed diagnosis can lead to serious consequences and even death.
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