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Ischemic Postconditioning Mitigates Lipopolysaccharide-induced Acute Lung Injury in Rats.
In Vivo
October 2024
Department of Physiology, Trakya University Faculty of Medicine, Edirne, Turkey.
Article Synopsis
- Acute lung injury (ALI) is a serious condition with high mortality rates, characterized by damage to lung tissue and inflammation, yet lacks specific approved treatments.
- This study explored the use of ischemic post-conditioning to reduce lung injury in rats induced by lipopolysaccharide (LPS), examining its effects on inflammation and cell death.
- Results showed that remote ischemic post-conditioning successfully reduced inflammatory responses and apoptosis in lung tissue, indicating a potential therapeutic approach for treating LPS-induced ALI.
Thymoma-Related Chest Pain and Dyspnea in a Middle-Aged Caucasian Female With Myasthenia Gravis and Good's Syndrome: A Case Report.
Cureus
August 2024
Department of Obstetrics and Gynecology, South Central Regional Medical Center, Laurel, USA.
Thymomas are rare tumors originating from thymic tissue, often associated with various paraneoplastic syndromes that can pose significant clinical management challenges. Myasthenia gravis, one of the most common paraneoplastic syndromes linked to thymomas, is characterized by autoantibodies targeting the neuromuscular junction, leading to muscle weakness exacerbated by repetitive use. Good's syndrome, an adult-onset immunodeficiency associated with thymomas, results in hypogammaglobulinemia and susceptibility to opportunistic infections, which can be life-threatening.
View Article and Find Full Text PDFTargeting BRD4 with PROTAC degrader ameliorates LPS-induced acute lung injury by inhibiting M1 alveolar macrophage polarization.
Int Immunopharmacol
May 2024
Department of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Diseases, The First Affiliated Hospital (Shenzhen People's Hospital) and School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China. Electronic address:
Objectives: Acute lung injury (ALI) is a highly inflammatory condition with the involvement of M1 alveolar macrophages (AMs) polarization, eventually leading to the development of non-cardiogenic edema in alveolar and interstitial regions, accompanied by persistent hypoxemia. Given the significant mortality rate associated with ALI, it is imperative to investigate the underlying mechanisms of this condition so as to identify potential therapeutic targets. The therapeutic effects of the inhibition of bromodomain containing protein 4 (BRD4), an epigenetic reader, has been proven with high efficacy in ameliorating various inflammatory diseases through mediating immune cell activation.
View Article and Find Full Text PDFAcute respiratory distress syndrome heterogeneity and the septic ARDS subgroup.
Front Immunol
December 2023
Department of Critical Care Medicine, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Article Synopsis
- ARDS is a severe lung injury characterized by inflammation and damage to lung cells, leading to fluid buildup and is caused by both in-lung and other body factors.
- Researchers have been struggling with ARDS treatment effectiveness, but using latent class analysis to identify subgroups has shown promise for targeted therapies.
- Sepsis is a major cause of ARDS, linked to more severe symptoms and higher mortality, making the understanding of its immune mechanisms and focused treatments crucial for improving patient outcomes.*
Kaempferol and ginsenoside Rg1 ameliorate acute hypobaric hypoxia induced lung injury based on network pharmacology analysis.
Toxicol Appl Pharmacol
December 2023
School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, China; Department of Intensive Care Medicine, The Third People's Hospital of Chengdu/Affiliated Hospital of Southwest Jiaotong University, Chengdu, China. Electronic address:
Acute hypobaric hypoxia at high altitude can cause fatal non-cardiogenic high altitude pulmonary edema. Anti-inflammatory and anti-oxidant treatments appear to be a prospective way to alleviate acute hypoxia lung injury. Kaempferol (KA) and ginsenoside Rg1 (GRg1) can be isolated and purified from ginseng with anti-inflammatory, antioxidant, anti-carcinogenic, neuroprotective, and antiaging effects.
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