This article focuses on the cellular, biochemical, and molecular pharmacology of antifolates and how a basic understanding of the mechanism of action of methotrexate, its cytotoxic determinants, mechanisms of resistance, and transport into and out of cells has led to the development of a new generation of antifolates, a process that continues in the laboratory and in the clinics. New approaches to folate-based cancer chemotherapy are described based on the targeted delivery of drugs to malignant cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777421 | PMC |
| http://dx.doi.org/10.1016/j.hoc.2012.02.002 | DOI Listing |
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