A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry & Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose.
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| http://dx.doi.org/10.1016/j.chembiol.2012.04.004 | DOI Listing |
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