The existence of semantic access disorders is now well established, however the precise cognitive and anatomical underpinnings are still debated. Here we describe the case of a patient that became aphasic after the resection of a left frontal glioma. Detailed lesion reconstruction indicates that the lesion was mostly restricted to the left dorsal and ventral prefrontal cortices and the underlying white matter, but sparing temporal lobes. Critically, the patient showed all the signs of refractory semantic access dysphasia, supporting the association between this syndrome and damage to left prefrontal areas likely to subserve retrieval and selection mechanisms for verbal material.
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http://dx.doi.org/10.1080/13554794.2011.654212 | DOI Listing |
BMC Geriatr
December 2024
Department of Health Sciences, Institute of Nursing, ZHAW Zurich University of Applied Sciences, Katharina-Sulzer Platz 9, CH-8400, Winterthur, Switzerland.
Background: Dementia is a progressive and terminal illness. Symptoms are present for people with dementia across all stages, leading to poor quality of life and considerable carer burden. In acute and community care services, no holistic, person-centred outcome tools are available for nurses and informal caregivers to measure symptoms and needs from the person`s with dementia point of view.
View Article and Find Full Text PDFJ Speech Lang Hear Res
December 2024
Escuela de Gobierno, Universidad Torcuato Di Tella, Buenos Aires, Argentina.
Purpose: Children with hearing loss (CHL) who use hearing devices (cochlear implants or hearing aids) and communicate orally have trouble comprehending sentences with noncanonical order. This study explores sentence comprehension strategies in Spanish-speaking CHL, focusing on their ability to integrate morphosyntactic cues (word order, morphological case marking) with verbs differing in their syntax-to-semantics configuration.
Method: Fifty-eight Spanish-speaking CHL and 58 children with typical hearing (CTH) with a hearing age of 3;5-7;8 (years;months; i.
Contemp Clin Trials Commun
December 2024
Department of Communications Sciences and Disorders, University of South Carolina, Columbia, SC, USA.
Background And Purpose: Despite comprehensive evidence that supports the utility of aphasia therapy in persons with chronic (≥6 months) stroke-induced aphasia, the amount of therapy provided to patients in the United States is typically far less than what is likely necessary to maximize recovery. Two potential contributors to this discrepancy are limited access to rehabilitation services due to the availability of providers and logistical difficulties with transportation. One way to increase access to aphasia therapy is to rely on telerehabilitation.
View Article and Find Full Text PDFSTAR Protoc
December 2024
BGI Research, Shenzhen 518083, China; BGI Research, Hangzhou 310030, China. Electronic address:
The scarcity of zebrafish-specific motif databases presents a challenge to the analysis of transcription factor (TF) motif within zebrafish single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) data, thus hindering the identification of regulatory elements throughout zebrafish embryonic development. Here, we provide a protocol to analyze single-nucleus chromatin accessibility dataset during zebrafish early embryogenesis. We describe steps for fragment file retrieval, sample integration, quality control, Latent Semantic Indexing (LSI) clustering, and peak calling via ArchR.
View Article and Find Full Text PDFJ Biomed Inform
December 2024
Department of Management Information Systems, University of Arizona, Tuscon, AZ, USA.
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