[Preliminary results of effectiveness of two schemes of controlled ovarian hyperstimulation protocols with recombinant foliculle stimulating hormone in intrauterine insemination cycles].

Background: The intrauterine insemination (IUI) is the first line treatment in different infertility situations.

Objective: To compare the efficacy of two protocols of controlled ovarian hyper stimulation (COHS) with recombinant Follicle Stimulating hormone (rFSH) (75 vs. 150 UI/day) plus IUI, in terms of pregnancy rate, multiple pregnancies, ovarian hyper stimulation syndrome and ovarian stimulation features.

Materials And Methods: Prospective study, sequential assignment, included 35 patients that had 44 cycles of IUI. They were assigned in to two groups, group 1 that started controlled ovarian hiperestimulation with 75 and 2 with 150 UI/day of recombinant rFSH.

Results: We found statistically significant difference between groups in: dose of rFSH, amount of stimulation days, number of mature follicles and estradiol blood levels on the day of use of the GnRHant and hCG injection day. The pregnancy rate between group 1 and 2 were 9.1 vs. 27.2%, respectively. Of the 8 pregnancies, 75% were achieving in group 2. The twin pregnancy rate was 2.2% and there were no cases of OHSS.

Conclusions: Although without significant difference between groups we found a clear trend to achieve a better pregnancy rate with the 150 UI/day protocol without a significant raise in multiple pregnancy rate nor OHSS. The multifollicular development was associated to group 2 seems to be related to the better pregnancy rate achieved by the same group.