A single mouse Lgr5-positive colon stem cell can be expanded into a three-dimensional organoid that, after transplant, contributes to the repair of injured colon epithelia in a mouse model of colitis.
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Rolling schedule design for the ESP rolling process based on NSGA-II-DE.
ISA Trans
January 2025
State Key Laboratory of Rolling and Automation, Northeastern University, Shenyang, Liaoning 110819, China; Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking, Ministry of Education, Shenyang 110819, China. Electronic address:
Multiple processes connected closely during the endless strip production (ESP) rolling, it is difficult to obtain the global optimal solution by multi-objective modelling of a single process, and the parameters to be optimized coupled with each other. To obtain the optimal solution, a multi-objective optimization model combining the power consumption, product quality, and loading balance was proposed for the design of an ESP rolling schedule. The thickness and heating temperature were simultaneously taken as the decision variables for coupling the temperature and loading in the rolling process, and the non-dominated sorting genetic algorithm-II (NSGA-II) based on differential evolution (NSGA-II-DE) was applied to obtain the Pareto solutions.
View Article and Find Full Text PDFBlink completeness and rate in dry eye disease: An investigator-masked, prospective registry-based, cross-sectional, prognostic study.
Cont Lens Anterior Eye
January 2025
Department of Ophthalmology, Aotearoa New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand. Electronic address:
Purpose: To investigate the prognostic ability of blink rate and the proportion of incomplete blinking to predict dry eye disease diagnosis, as defined by the TFOS DEWS II criteria.
Methods: A total of 453 community residents (282 females, 171 males; mean ± SD age, 37 ± 19 years) were recruited in an investigator-masked, prospective registry-based, cross-sectional, prognostic study. Dry eye symptomology, tear film quality, and ocular surface characteristics were assessed in a single clinical session, and blink parameters evaluated by an independent masked observer.
Self-Contamination Risk and Failure Modes During High-Level PPE Doffing: A Comparison of Two Powered Air Purifying Respirator (PAPR) Hoods: A Pilot Study.
Am J Infect Control
January 2025
Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA. Electronic address:
Background: Personal protective equipment (PPE) doffing protocols can reduce risks of pathogen self-contamination. Powered air purifying respirators (PAPRs) may increase these risks. This study compares viral contamination and errors during simulated doffing of single layer vs double layer hood PAPRs.
View Article and Find Full Text PDFMulti-omics analyses of early-onset familial Alzheimer's disease and Sanfilippo syndrome zebrafish models reveal commonalities in disease mechanisms.
Biochim Biophys Acta Mol Basis Dis
January 2025
Alzheimer's Disease Genetics Laboratory, School of Molecular and Biomedical Sciences, Faculty of Sciences, Engineering and Technology, The University of Adelaide, North Terrace Campus, Adelaide, SA 5005, Australia.
Sanfilippo syndrome (mucopolysaccharidosis type III, MPSIII) causes childhood dementia, while Alzheimer's disease is the most common type of adult-onset dementia. There is no cure for either of these diseases, and therapeutic options are extremely limited. Increasing evidence suggests commonalities in the pathogenesis of these diseases.
View Article and Find Full Text PDFSimultaneous activation of different subtypes of dopamine receptors may lead to activation of homeostatic sleep regulatory mechanisms.
Pharmacol Biochem Behav
January 2025
In vivo Electrophysiology Research Group, Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary. Electronic address:
Dopaminergic system gains importance in homeostatic sleep regulation, but the role of different dopamine receptors is not well-defined. 72 h rat electrocorticogram and sleep recordings were made after single application of dopaminergic drugs in clinical use or at least underwent clinical trials. The non-selective agonist apomorphine evoked short pharmacological sleep deprivation with intense wakefulness followed by pronounced sleep rebound.
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