Purpose: Assessing two technology-based programs for reducing toe walking and breaks during walking of two men with multiple disabilities, respectively.
Method: The men were involved in separate single-case studies, each of which was carried out according to an ABAB design. The technology included a microprocessor with specific software, optic sensors, and visual plus vibrotactile or auditory systems for presenting preferred stimuli. In Study I, the man received 1 s of preferred flickering lights and vibratory input for each step performed with the heel of the left foot touching the ground or coming close to it (i.e. within a 2-mm distance). In Study II, the other man received 10 s of preferred music anytime he crossed one of the small marks present along the travel routes.
Results: The B phases showed that (a) the man included in Study I increased the percentages of left- and right-foot steps performed with the heels touching or nearing the ground to above 85% and 70%, respectively, and (b) the man included in Study II walked with very few breaks.
Conclusion: Technology-based programs can be highly effective in helping persons with multiple disabilities improve their walking behavior.
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http://dx.doi.org/10.3109/17483107.2012.678030 | DOI Listing |
Sensors (Basel)
January 2025
Department of Information Engineering, University of Florence, 50139 Florence, Italy.
The increasing demand for personalized healthcare, particularly among individuals requiring continuous health monitoring, has driven significant advancements in sensor technology. Wearable, non-continuous monitoring, and non-contact sensors are leading this innovation, providing novel methods for monitoring vital signs and physiological data in both clinical and home settings. However, there is a lack of comprehensive comparative studies assessing the overall functionality of these technologies.
View Article and Find Full Text PDFMicroorganisms
January 2025
State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
ε-poly-l-lysine (ε-PL), a natural food preservative, has garnered widespread attention. It is mainly produced by , but the production by wild-type strains fails to meet the demands of industrialization. To address this issue, adaptive laboratory evolution (ALE) was successfully employed in this study, subjecting CICC 11022 to environmental stresses such as acidic pH and antibiotics (rifampicin, gentamicin, and streptomycin).
View Article and Find Full Text PDFCancers (Basel)
January 2025
Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 9030 Old Georgetown Road, Bethesda, MD 20892-8200, USA.
Background: Oral therapeutic options for plexiform neurofibromas (PNs) in individuals with neurofibromatosis type 1 (NF1) are receiving attention in clinical research. The MEK inhibitor (MEKi) Selumetinib is FDA-approved in children ages 2+ years with inoperable PNs, and shows activity in adults. Prolonged therapy with selumetinib is necessary to maintain tumor reduction.
View Article and Find Full Text PDFFront Surg
January 2025
Department of Traditional Chinese Medicine, Guilin People's Hospital, Guilin, Guangxi, China.
Introduction: To develop an intelligent system based on artificial intelligence (AI) deep learning algorithms using deep learning tools, aiming to assist in the diagnosis of lumbar degenerative diseases by identifying lumbar spine magnetic resonance images (MRI) and improve the clinical efficiency of physicians.
Methods: The PP-YOLOv2 algorithm, a deep learning technique, was used to design a deep learning program capable of automatically identifying the spinal diseases (lumbar disc herniation or lumbar spondylolisthesis) based on the lumbar spine MR images. A retrospective analysis was conducted on lumbar spine MR images of patients who visited our hospital from January 2017 to January 2022.
J Geriatr Oncol
January 2025
Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., Tampa, FL 33612, United States of America; Tampa General Hospital Cancer Institute, 1 Tampa General Circle Tampa, FL 33606-3571, United States of America.
Introduction: Older adults are often prescribed oral anticancer agents (OAAs). Technology-based interventions may offer medication and symptom support. We aimed to evaluate technology ownership, use, and preferred design features of a supportive web-based program using a multimethod design utilizing surveys and semi-structured interviews.
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