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Relationship of selective complement markers with schizophrenia.

J Neuroimmunol

February 2022

Department of Pathology and Laboratory Medicine, Kulliyyah of Medicine, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia. Electronic address:

Immune system dysregulation may be involved in schizophrenia, but biomarker studies have thus far reported inconsistent findings. The relationship of plasma levels of complement markers C3 and C4, with schizophrenia, sociodemographic and clinico-psychological factors were here studied in 183 patients and 212 controls. C3 and C4 levels were significantly higher in the patients and in subjects with elevated C-reactive protein (CRP), and positively correlated with body mass index (BMI) (p < 0.

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Clinico-neurological, instrumental and psychological methods were used to examine 35 patients at the of 55-70 years with early stages of cerebrovascular insufficiency. It was found out that subjective signs of cerebral vascular disorders were likely to be due to nonspecific cerebral dysfunction and associated with psychical dysadaptation. The degree of memory and attention disorders negatively correlated with intensity of mental activity.

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Altogether 345 patients with rheumatic fever operated on for heart disease were examined for clinicopsychological correlations and their importance for patients' adaptation to work. Cardiovascular function was estimated with the aid of clinical and instrumental methods (ECG, echocardiography, bicycle ergometry). The psychological personality traits were examined by Quetelet's 16-factorial questionnaire, the type of the attitude towards disease by a personality questionnaire developed by the V.

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A study was made of mental rigidity in patients suffering from anorexia nervosa and their relatives using the Tomsk rigidity questionnaire. Based on examinations of 40 patients with anorexia nervosa, 22 of whom suffered from schizophrenia, 18 with borderline pathology (16 with an active method of weight losing, 24 with the bulimic variant of anorexia nervosa) and of 58 close relatives (mothers, fathers, sisters) the data were obtained on the level of mental rigidity. In the patients' group, it was found to depend to a greater measure on the stage of anorexia nervosa, whereas in the relatives, on the nosological appurtenance of the syndrome in their children.

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