AI Article Synopsis
- The study aimed to investigate how genetic variations in the CYP1B1 gene might affect the risk of developing primary open-angle glaucoma (POAG).
- A systematic literature review and meta-analysis method were used, analyzing data from six studies to assess the relationship between CYP1B1 polymorphisms and POAG.
- The findings revealed no significant link between CYP1B1 genetic variations and POAG, suggesting that these polymorphisms and their combined effect do not contribute to the disease risk.
Article Abstract
Purpose: To examine the effects of genetic polymorphisms in cytochrome P450, subfamily 1, polypeptide 1 (C1P1B1) on primary open-angle glaucoma (POAG).
Methods: A systematic literature search was performed, and random-effects meta-analyses were used to evaluate genetic polymorphisms in CYP1B1 with POAG. A gene-based analysis was conducted to investigate the cumulative effects of genetic polymorphisms in CYP1B1.
Results: A total of six studies from published papers were included in our analysis. Random-effects meta-analyses failed to detect any significant association of POAG with genetic polymorphisms in CYP1B1, including rs180040, rs1056836, rs10012, rs1056827, rs1056837, and rs2567206. The gene-based analysis indicated that the cumulative effect of genetic polymorphisms in CYP1B1 is not associated with POAG (p>0.50).
Conclusions: We did not find any evidence of strong association of POAG with CYP1B1 genetic polymorphisms and their cumulative effect.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324367 | PMC |
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