Aim: To evaluate for the first time the protein and mRNA expression of 14-3-3ε in gastric carcinogenesis.
Methods: 14-3-3ε protein expression was determined by western blotting, and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.
Results: Authors observed a significant reduction of 14-3-3ε protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue. Reduced levels of 14-3-3ε were also associated with diffuse-type GC and early-onset of this pathology. Our data suggest that reduced 14-3-3ε may have a role in gastric carcinogenesis process.
Conclusion: Our results reveal that the reduced 14-3-3ε expression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcinogenesis process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319950 | PMC |
| http://dx.doi.org/10.3748/wjg.v18.i13.1531 | DOI Listing |
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