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| http://dx.doi.org/10.1016/j.jaad.2011.05.028 | DOI Listing |
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Background: The associations of PM mass and various adverse health outcomes have been widely investigated. However, fewer studies focused on the potential health impacts of PM components, especially for dementia and Alzheimer's diseases (AD).
Methods: We constructed a nationwide population-based open cohort study among Medicare beneficiaries aged 65 or older during 2000-2018.
Evaluating Chemical Transport and Machine Learning Models for Wildfire Smoke PM: Implications for Assessment of Health Impacts.
Environ Sci Technol
December 2024
Doerr School of Sustainability, Stanford University, Stanford, California 94305, United States.
Growing wildfire smoke represents a substantial threat to air quality and human health. However, the impact of wildfire smoke on human health remains imprecisely understood due to uncertainties in both the measurement of exposure of population to wildfire smoke and dose-response functions linking exposure to health. Here, we compare daily wildfire smoke-related surface fine particulate matter (PM) concentrations estimated using three approaches, including two chemical transport models (CTMs): GEOS-Chem and the Community Multiscale Air Quality (CMAQ) and one machine learning (ML) model over the contiguous US in 2020, a historically active fire year.
View Article and Find Full Text PDFGenomic analysis of Zhou8425B, a key founder parent, reveals its genetic contributions to elite agronomic traits in wheat breeding.
Plant Commun
December 2024
State Key Laboratory of Wheat and Maize Crop Science, Henan Center for Crop genomics and Rice Engineering, College of Agronomy, Longzi Lake Campus, Henan Agricultural University, Zhengzhou 450046, China; National Wheat Engineering Research Center, College of Agronomy, Henan Agricultural University, Longzi Lake Campus, Zhengzhou 450046, China. Electronic address:
High-quality genome information is essential for efficiently deciphering and improving crop traits. Here we report a highly contiguous and accurate hexaploid genome assembly for the key wheat breeding parent Zhou8425B, an elite 1BL/1RS translocation line with durable adult plant resistance (APR) against yellow rust (YR) disease. By integrating HiFi and Hi-C sequencing reads, a 14.
View Article and Find Full Text PDFNative Valve and Native Neo-Sinus Remodeling Following Transcatheter Aortic Valve Replacement.
Circ Cardiovasc Interv
December 2024
Cardiovascular Translational Laboratory, Providence Research and Centre for Heart Lung Innovation, Vancouver, British Columbia, Canada (J.Y., H.G., J.J., A.L., J.G.W., J.S., D.M., S.L.S.).
Background: Transcatheter aortic valve replacement (TAVR) pushes aside the diseased native aortic valve and creates a native neo-sinus bordered by the aortic root wall and the displaced native valve. There are limited data on the progression of native valve disease post-TAVR and no previous analysis of the native neo-sinus.
Methods: Native aortic valves and native neo-sinus explants obtained post-TAVR were evaluated histologically (hematoxylin and eosin, Movat pentachrome, and Martius Scarlet Blue stains) and by immunohistochemistry (TGF-β1 [transforming growth factor-beta 1], FAP [fibroblast activation protein], and ALP [alkaline phosphatase]) to assess disease mechanisms.
Importance: Intense wildfires affecting residential populations are increasingly frequent. However, the adverse cardiopulmonary consequences to patients from remote wildfire smoke exposure is uncertain.
Objective: To investigate the association between wildfire smoke originating in Western Canadian provinces with cardiopulmonary disease burden in sociodemographically heterogenous populations in the Eastern US.
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