Objective: To analyze rosmarinic acid in Prunella vulgaris and its effect on the activity of alpha-glycosidase.
Methods: Qualitative and quantitative analyses of Rosmarinic acid in Prunella vulgaris were carried out by HPLC. The activity of different micro reaction systems like alpha-amylase, alpha-glucosidase and alpha-maltase, which were added to Rosmarinic acid and Acarbose, was determined by Bernfeld, pNPG and GOD.
Results: The contents of Rosmarinic acid in the aqueous extract and its dry powder, and extractum of Prunella vulgaris were 0.1494, 0.1657 and 0.2739 mg/g respectively, equal to crude drug. The Rosmarinic acid inhibited alpha-glycosidase, and its inhibition from alpha-maltase in small intestine was noncompetitive.
Conclusion: The aqueous extract of Prunella vulgaris and its extractum's inhibition from alpha-glycosidase is related to Rosmarinic acid.
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