Detailed morphological and cytochemical investigation of blood leukocytes was performed in minks of three genotypes: dark-brown minks (n=10), which had the color resembling that of the wild type, mutant silver-blue (p/p) minks (n=10), and sapphire minks (a/a p/p) (n=10). The sapphire minks were demonstrate to have a hereditary defect of leukocyte granules containing peroxidase, nonspecific esterases and non-enzymatic cationic protein. These granules have abnormally large size, the neutrophil cytoplasm contains one to several abnormal granules, they are numerous in eosinophil and basophil cytoplasm and rare in lymphocytes and monocytes. Morphological and cytochemical features indicate the similarity of hereditary leukocytes pathology of sapphire mink with that one found in human Chediak-Higashi syndrome.
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