Whether global health interventions target diseases (vertical), systems (horizontal) or both (diagonal), they must address the challenge of delivering services in very remote areas of poor countries with inadequate infrastructure. The primacy of this challenge has been underscored by persistent service-delivery difficulties despite several large financial commitments - the latest, US $363 million in the January 2012 London Declaration. Community-driven approaches, pioneered in river blindness control, show that engaging communities can maximise access and performance. This experience should inform a paradigm shift in disease control whereby communities are empowered to extend health service access themselves.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.pt.2012.03.002 | DOI Listing |
SLAS Technol
December 2024
Center for Biomedical Engineering, School of Engineering, Brown University, Providence, RI 02912, USA. Electronic address:
Automated liquid handlers are fundamental in modern life science laboratories, yet their high costs and large footprints often limit accessibility for smaller labs. This study presents an innovative approach to decentralizing a liquid handling system by converting a low-cost 3D printer into a customizable and accurate liquid handler. The Personal Automated Liquid Handler (PALH) system, costing ∼$400, incorporates a single-channel pipet, custom 3D-printed components, and open-source software for personalized workflows, allowing researchers to build and modify the system for specific experimental needs.
View Article and Find Full Text PDFArts Health
December 2024
Department of Urban & Regional Planning, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL, USA.
Background: PhotoVoice - a series of workshops involving participatory photography and narrative-building - was employed in the rural town of Comerío, Puerto Rico (PR) to describe disaster recovery in a rural setting and foster policy dialogue.
Methods: Using PhotoVoice workshops and ethnographic observations, the project describes how women affiliated with a local community-based organization described the priorities for disaster recovery in visual images and narratives. We draw analytically upon theories of intersectionality and coloniality to describe socio-structural and community factors that shape community health in the context of ongoing disasters.
Front Chem
November 2024
African Society for Bioinformatics and Computational Biology, Cape Town, South Africa.
Introduction: Homology modeling is a widely used computational technique for predicting the three-dimensional (3D) structures of proteins based on known templates,evolutionary relationships to provide structural insights critical for understanding protein function, interactions, and potential therapeutic targets. However, existing tools often require significant expertise and computational resources, presenting a barrier for many researchers.
Methods: Prostruc is a Python-based homology modeling tool designed to simplify protein structure prediction through an intuitive, automated pipeline.
Drugs R D
December 2024
Galapagos SASU, Romainville, France.
Background And Objective: This study provides a physiologically based pharmacokinetic (PBPK) model-based analysis of the potential drug-drug interaction (DDI) between cyclosporin A (CsA), a breast cancer resistance protein transporter (BCRP) inhibitor, and methotrexate (MTX), a putative BCRP substrate.
Methods: PBPK models for CsA and MTX were built using open-source tools and published data for both model building and for model verification and validation. The MTX and CsA PBPK models were evaluated for their application in simulating BCRP-related DDIs.
BMC Public Health
December 2024
Surgery, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Background: Communities have an important role to play in disaster and emergency planning and response. Yet community members are not typically engaged in official planning activities, including plans for mass immunization clinics during infectious disease emergencies, such as the COVID-19 pandemic. This qualitative study explores one case of a community driven effort to implement a COVID-19 mass vaccination clinic in Cobourg, Ontario, Canada.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!