AI Article Synopsis
- The study analyzed treatment outcomes for Extramammary Paget's disease (EMPD) in ethnic Chinese over a 20-year period, focusing on surgical interventions.
- Local recurrence occurred in 14.6% of patients, with different methods used for repairing surgical defects, including skin grafts and flaps.
- Dermal invasion was linked to a higher risk of metastasis; thus, preoperative screening for internal malignancies is recommended for all patients.
Article Abstract
Background. To examine the results of treatment of Extramammary Paget's disease (EMPD) in ethnic Chinese. Method. Between 1990 and 2010, patients treated for EMPD were reviewed. Data were analyzed retrospectively. Results. Forty-eight patients were treated by surgical resection. Local recurrence rate was 14.6%. The postresection defects were repaired by primary closure (8.3%), partial thickness skin graft (72.9%), or local/regional flaps (18.8%). Dermal invasion was found in 9 patients (18.8%). Seven patients (14.6%) developed regional lymph node metastasis (concurrent with surgery, n = 1; subsequent to surgery, n = 6), and 3 patients (6.3%) had systemic metastasis after surgery. The presence of dermal invasion was associated with significantly higher incidence of regional lymph nodes and systemic metastasis. The incidence of associated internal malignancy was 8.3%. Conclusion. The mainstay of treatment for EMPD is surgery. Pathological dermal invasion increases the chance of regional lymph node as well as systemic metastasis. The association with internal malignancy warrants preoperative endoscopic examination in all patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303748 | PMC |
| http://dx.doi.org/10.1155/2012/416418 | DOI Listing |
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