Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317601 | PMC |
| http://dx.doi.org/10.2149/tmh.2011-S08 | DOI Listing |
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