In contrast to the bony fishes, particularly the teleosts, the integument of elasmobranchs is rather unknown. Therefore, a description of the basic structural and functional features of shark and ray skin is given, based on a review of the literature and published or unpublished findings of the authors. The latter aspect makes it possible to document in more detail the specific structure of the skin layers regarding, particularly, the epidermis and its cell spectrum, the more or less robust dermis with its specific features, the very special scales with their derivates and the sophisticated sensoric integumental equipment. As far as possible, all important structures are discussed including their typical biological functions and results from applied scientific work. To some extent the information given is evaluated as compared with the much broader knowledge from the Osteichthyes.
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http://dx.doi.org/10.1111/j.1095-8649.2011.03207.x | DOI Listing |
Heliyon
January 2025
College of Information Science and Electronic Engineering, Zhejiang University, Hangzhou, 310027, China.
Objective And Rationale: Children's clinical pain phenotypes are complex, and there is a lack of objective biological diagnostic markers and cognitive patterns. Detecting physiological signals through wearable devices simplifies disease diagnosis and holds the potential for remote medical applications.
Method And Results: This research established a pain recognition model based on AI skin potential (SP) signal analysis.
J Transl Med
January 2025
Department of Academic Research, The Second Hospital of Shandong University, Jinan, Shandong, China.
Background: To elucidate the genetic and molecular mechanisms underlying psoriasis by employing an integrative multi-omics approach, using summary-data-based Mendelian randomization (SMR) to infer causal relationships among DNA methylation, gene expression, and protein levels in relation to psoriasis risk.
Methods: We conducted SMR analyses integrating genome-wide association study (GWAS) summary statistics with methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and protein quantitative trait loci (pQTL) data. Publicly available datasets were utilized, including psoriasis GWAS data from the European Molecular Biology Laboratory-European Bioinformatics Institute and the UK Biobank.
Sci Rep
January 2025
Department of Burn and Plastic Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Hepatocyte growth factor (HGF) is a substance that stimulates the proliferation of hepatocytes which promote healing. We developed a macrophage membrane-encapsulated nanosphere drug delivery system containing HGF for the study of burn wound healing. Twenty-seven Sprague-Dawley rats were randomly divided into three groups: a saline control (NS) group, an engineered macrophage membrane-encapsulated nanospheres (ETMM@NPS) group, and an engineered macrophage membrane-encapsulated nanospheres treatment with HGF-loaded gene (HGF@ETMM@NPS) group.
View Article and Find Full Text PDFAm J Clin Dermatol
January 2025
Department of Dermatology, Shanghai Skin Disease Hospital, Tongji University, Shanghai, 200443, China.
Background: Family history (FH) of psoriasis has been implicated as a risk factor for developing psoriasis. However, whether FH also carries information on clinical presentation and treatment response to biological agents in patients with psoriasis remains unclear.
Objective: This prospective, multicenter observational study aimed to analyze the clinical presentation and efficacy differences between patients with psoriasis with and without a FH.
Carbohydr Polym
March 2025
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:
The treatment and monitoring of infected skin wounds present significant clinical challenges. Herein, a multifunctional poly(deep eutectic solvent) (PDES) electroactive hydrogel is developed by optimizing the components and the ratio of hydrogen donors and acceptors, achieving well wound hemostasis, wound healing, and monitoring administration performace. The PDES hydrogel dressing exhibits mechanical properties, including high toughness, fatigue resistance (over 9000 compression cycles), and superior skin adhesion (over 70 kPa).
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