Purpose. To investigate the vasomotive activity upon the external ophthalmic artery of vasointestinal peptide (VIP) and neuropeptide Y (NPY) using a previously developed model. Methods. Isolated rabbit eyes (n = 12) were perfused in situ with tyrode through the external ophthalmic artery. Effects of intra-arterial injections of NPY 200 μg/ml (Group A; n = 6) and VIP 200 μg/ml (Group B; n = 6) on the recorded pressure were obtained. For statistical analysis, Student's paired t-test and Fast Fourier Transform were used. Results. Spontaneous oscillations were observed before any drug administration in the 12 rabbit models. NPY produced an increase in total vascular resistance and a higher frequency and amplitude of oscillations, while VIP evoked the opposite effects. Conclusions. This study provides evidence of vasomotion in basal conditions in rabbit external ophthalmic artery. Concerning drug effects, NPY increased arterial resistance and enhanced vasomotion while VIP produced opposite effects which demonstrates their profound influence in arterial vasomotion.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306996 | PMC |
| http://dx.doi.org/10.1155/2012/498565 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Estimating the contribution of early and late noise in vision from psychophysical data.
J Vis
January 2025
Neural Information Processing Group, University of Tübingen, Tübingen, Germany.
Human performance in psychophysical detection and discrimination tasks is limited by inner noise. It is unclear to what extent this inner noise arises from early noise (e.g.
View Article and Find Full Text PDFPurpose: The purpose of this study is to evaluate the impact of foveal bulge presence on visual acuity (VA) in patients with diabetic macular edema (DME) and retinal vein occlusion (RVO).
Methods: Spectral-domain optical coherence tomography (SD-OCT) scans were conducted on 22 DME patients and 20 RVO patients. Ordinary least squares (OLS) regression was employed to analyze the association between VA and the presence of the foveal bulge, as well as factors such as sex, age, central foveal thickness, various line scans of the fovea, and the external limiting membrane (ELM).
Differentiating Choroidal Melanomas and Nevi Using a Self-Supervised Deep Learning Model Applied to Clinical Fundoscopy Images.
Ophthalmol Sci
November 2024
Liverpool Ocular Oncology Research Group, Department of Eye and Vision Science, Institute of Life Course and Medical Sciences (ILCaMS), University of Liverpool, Liverpool, United Kingdom.
Purpose: Testing the validity of a self-supervised deep learning (DL) model, RETFound, for use on posterior uveal (choroidal) melanoma (UM) and nevus differentiation.
Design: Case-control study.
Subjects: Ultrawidefield fundoscopy images, both color and autofluorescence, were used for this study, obtained from 4255 patients seen at the Liverpool Ocular Oncology Center between 1995 and 2020.
Dahuang-Gancao Decoction Ameliorates Testosterone-Induced Androgenetic Alopecia in Mice.
J Ethnopharmacol
January 2025
Eye School of Chengdu University of Traditional Chinese Medicine. Ineye Hospital of Chengdu University of Traditional Chinese Medicine, KeyLaboratory of Sichuan Province Ophthalmopathy Prevention & Cureand Visual Function Protection with Traditional Chinese Medicine Laboratory. Electronic address:
Ethnopharmacological Relevance: Dahuang-Gancao decoction (DGD) is a traditional Chinese medicinal formula that is recorded in the Synopsis of the Golden Chamber, and is widely used to treat damp-heat in the body. Since the pathological factors of androgenetic alopecia (AGA) also reflect damp-heat blockage, DGD has great potential for the treatment of AGA and has been used effectively in clinical practice.
Aim Of The Study: The aim of the study was to investigate whether external application of DGD could promote the activation and proliferation of hair follicle stem cells (HFSCs) and improve AGA through the Wnt/β-catenin pathway.
Reduction in EEG theta power as a potential marker for spatial disorientation during flight.
Sci Rep
January 2025
Department of Cognitive and Brain Sciences, Ben-Gurion University of the Negev, 1 Ben-Gurion Blvd, Beer-Sheva, Israel.
During flight, spatial disorientation (SD) commonly occurs when a pilot's perception conflicts with the aircraft's actual motion, attitude, or position. A prevalent form of SD is the somatogyral illusion, which is elicited by constant speed rotation and causes a false perception of motion in the opposite direction when the rotation ceases. This research aimed to investigate changes in brain activity that occur when experiencing a somatogyral illusion by simulating conditions closely mimicking flight conditions to gain insight into how to better manage this illusion during flight.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!