AI Article Synopsis
- The study investigates the safety of aerosol immunization for the MMR vaccine, highlighting concerns about potential virus transmission to vaccine administrators or their contacts.
- It compares clinical and serological outcomes between young adults receiving the vaccine via aerosol versus injection and their matched contacts.
- Findings show no significant differences in adverse events or immune responses between vaccinees and their contacts, suggesting aerosol immunization is a safe method.
Article Abstract
Although numerous operative and immunological advantages accompany aerosol immunization, potential vaccine virus transmission from the aerosol device to vaccine administrators or from aerosol vaccinees to their contacts requires further study. We conducted a clinical and serological follow-up study of vaccine administrators and matched classroom or household contacts of young adults who received the MMR vaccines by aerosol or injection. Differences in incidence of clinical adverse events between vaccinees and contacts were not statistically significant. No seroresponses to any components of MMR vaccine were noted among 25 matched contacts of persons receiving injected vaccines, and only one equivocal seroresponse was noted among 25 matched contacts of aerosol recipients. No seroresponses were observed in 3 persons who administered aerosol vaccine. The composite findings of this study provide additional evidence of the safety of this approach.
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| http://dx.doi.org/10.1016/j.biologicals.2012.03.002 | DOI Listing |
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