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Mutation accumulation may be a minor force in shaping life history traits. | LitMetric

AI Article Synopsis

  • The text explores whether aging (senescence) is a result of beneficial trade-offs between younger and older ages or negative mutations that arise later in life.
  • By combining adaptive and nonadaptive processes in a model using Penna's bit-strings, the study analyzes how different genetic patterns affect life history strategies and fitness over generations.
  • The findings indicate that harmful mutations primarily accumulate at ages that don't significantly impact fitness and have little influence on the optimal age for maturity, suggesting that life's timing and development are mainly shaped by adaptive processes rather than nonadaptive mutation accumulation.

Article Abstract

Is senescence the adaptive result of tradeoffs between younger and older ages or the nonadaptive burden of deleterious mutations that act at older ages? To shed new light on this unresolved question we combine adaptive and nonadaptive processes in a single model. Our model uses Penna's bit-strings to capture different age-specific mutational patterns. Each pattern represents a genotype and for each genotype we find the life history strategy that maximizes fitness. Genotypes compete with each other and are subject to selection and to new mutations over generations until equilibrium in gene-frequencies is reached. The mutation-selection equilibrium provides information about mutational load and the differential effects of mutations on a life history trait--the optimal age at maturity. We find that mutations accumulate only at ages with negligible impact on fitness and that mutation accumulation has very little effect on the optimal age at maturity. These results suggest that life histories are largely determined by adaptive processes. The non-adaptive process of mutation accumulation seems to be unimportant at evolutionarily relevant ages.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320907PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0034146PLOS

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