Objective: To compare the morphological difference between dermal tissue of normal skin and that of scar in rat, and to explore its structural pattern.
Methods: The full-thickness skin and the scar tissue formed 3 weeks after wound healing from SD rats were harvested as samples, which were prepared appropriately afterwards. Samples were scanned and imaged with synchrotron radiation technology, micro-CT, and phase-contrast imaging technology. The images were rebuilt with three-dimensional software.
Results: The micro-CT was materialized by using X-ray generated by synchrotron radiation light source. The structure of dermal tissues was clearly shown with the assistance of phase-contrast imaging technology in the process. It was demonstrated that the dermal tissues of normal skin of rat were mainly composed of collagenous fibers, which twined together to form an olive-like structure. These olive-like structures as basic units were arranged randomly in a certain way. The collagenous fibers in dermal tissue of the scar were arranged in a parallel manner, while some fibers were crooked and arranged in a disorderly manner.
Conclusions: Dermal tissue of normal skin in rat has stable three-dimensional structure, and its basic structure and manner of composition are obviously different from those of scar dermal tissue.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Clinical presentations and complications of lichen sclerosus: A systematic review.
J Dtsch Dermatol Ges
December 2024
Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.
Lichen sclerosus (LS) is a chronic, inflammatory dermatosis most commonly characterized by changes in skin pigmentation and pruritus, with associated dyspareunia and genital architectural changes. There are a variety of complications associated with LS, which further worsen a patient's health-related quality of life. A systematic review was conducted to summarize the literature regarding clinical features of LS, as well as LS-associated complications.
View Article and Find Full Text PDFRethinking BCC diagnosis: Automating concept-specific detection of BCC in dermatoscopic images.
J Dtsch Dermatol Ges
December 2024
Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, China.
Background: Basal cell carcinoma (BCC) is a prevalent type of skin cancer in which the inherent subjectivity of dermoscopy poses diagnostic challenges. Existing AI systems, which provide mainly image-level insights, lack the interpretability that is crucial for effective clinical decisions and patient education.
Patients And Methods: Our study developed a refined BCC dataset from the Human‒Machine Adversarial Model (HAM10000), which was annotated by clinicians to identify key diagnostic features.
Successful Multi-Modal Laser Intervention and Histopathological Evaluation of Multiple Glomangiomas.
Lasers Surg Med
December 2024
Department of Dermatology, Veterans Health Administration, San Antonio, Texas, USA.
Objectives: Glomangiomas are benign vascular malformations that exist within the spectrum of glomuvenous malformations which consist of varying amounts of glomus cells, vascular spaces, and smooth muscle. Glomangiomas are often treated due to associated pain, particularly when located on pressure areas such as the back or extensor surfaces, which can cause difficulty with certain activities and occupational functions. Histologically glomangiomas consist of prominent dilated vascular spaces lined by glomus cells typically situated in the deep-dermis to subcutaneous fat which limits treatment to modalities capable of reaching the depth of the tumor including excision, sclerotherapy, and laser therapy.
View Article and Find Full Text PDFAnatomy of Risk: Decoding the Predictors of Vascular Access Complications in Transcatheter Aortic Valve Replacement.
Catheter Cardiovasc Interv
December 2024
Department of Surgery, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota, United States.
Background: Despite advancements in valve implantation devices, vascular access complications (VAC) remain a significant cause of morbidity and mortality for those undergoing transcatheter aortic valve replacement (TAVR). We describe pre-operative imaging analysis of the aortoiliac and femoral arterial beds using the TransAtlantic intersociety consensus (TASC) score, ilio-femoral tortuosity, and procedural characteristics to identify anatomic risk factors predictive of VAC in TAVR.
Methods: Consecutive patients undergoing TAVR from 2012 to 2022 at a single North Dakota hospital were retrospectively reviewed.
Treatment of limb skin defect with self-made skin distractor.
BMC Musculoskelet Disord
December 2024
Orthopedic Research Institute of HeBei Province, Orthopedic Biomechanic Key Laboratory of Hebei Province, Trauma Emergency Center of Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China.
Objective: To investigate the effect of self-made skin distractor in the treatment of limb skin defects.
Methods: From September 2018 to January 2020, 15 cases of limb skin defects (16 wounds) were treated with self-designed skin distractor, including 13 males and 2 females, with an average age of 42 years (range, 9-73 years). The smallest area of skin defect was 6 cm×3 cm, the largest was 32 cm ×7 cm, with an average of 72.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!