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Reprogramming aerobic metabolism mitigates Streptococcus pyogenes tissue damage in a mouse necrotizing skin infection model.
Nat Commun
March 2025
Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, MO, USA.
Disease tolerance is a host response to infection that limits collateral damage to host tissues while having a neutral effect on pathogen fitness. Previously, we found that the pathogenic lactic acid bacterium Streptococcus pyogenes manipulates disease tolerance using its aerobic mixed-acid fermentation pathway via the enzyme pyruvate dehydrogenase, but the microbe-derived molecules that mediate communication with the host's disease tolerance pathways remain elusive. Here we show in a murine model that aerobic mixed-acid fermentation inhibits the accumulation of inflammatory cells including neutrophils and macrophages, reduces the immunosuppressive cytokine interleukin-10, and delays bacterial clearance and wound healing.
View Article and Find Full Text PDFMicro-gyms as a catalyst for healthy aging in university and healthcare settings: applications for the Semmelweis-EUniWell Workplace Health Promotion Model Program.
Geroscience
March 2025
Healthy Aging Section, European Public Health Association, Utrecht, The Netherlands.
Europe is experiencing a significant demographic shift, with aging populations posing economic and social challenges due to increased healthcare costs and a higher prevalence of age-related diseases. Hungary, in particular, faces these challenges acutely due to higher morbidity and mortality rates from a range of chronic age-related diseases and behavioral risk factors. Addressing these issues requires innovative approaches to promote healthy aging.
View Article and Find Full Text PDFGenome-wide mutagenesis identifies factors involved in MRSA vaginal colonization.
Cell Rep
March 2025
University of Colorado Anschutz Medical Campus, Department of Immunology and Microbiology, Aurora, CO, USA; Department of Veterans Affairs Eastern, Colorado Healthcare System, Aurora, CO, USA. Electronic address:
Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen that colonizes various body sites, including the nares, skin, and vagina. During pregnancy,colonization can lead to dysbiosis, adverse pregnancy outcomes, and invasive disease. To identify genes contributing to MRSA vaginal fitness, we performed transposon sequencing (Tn-seq) using a murine model of vaginal colonization, identifying over 250 conditionally essential genes.
View Article and Find Full Text PDFIban Kinship and Cooperation : A Test of the Ancestor-Descendant Conflict Model.
Hum Nat
March 2025
Department of Anthropology, University of Missouri, Columbia, MO, USA.
Humans often display extensive forms of prosocial behavior, frequently beyond what is predicted by inclusive fitness. This observation has led to various models attempting to explain the unique extent of human altruism. While many of these models have been empirically tested, one model, the ancestor-descendant conflict model, which is based on a maximum descendant-leaving strategy, has yet to be explicitly examined with observational human data.
View Article and Find Full Text PDFVisceral adipose tissue is related to interleukin 6 and resistin in juvenile idiopathic arthritis - a case-control study.
Rheumatol Int
February 2025
Section for Rheumatology, Oslo University Hospital, Oslo, Norway.
To compare visceral adipose tissue (VAT) mass, lipid profile, and selected adipokines/cytokines in patients with juvenile idiopathic arthritis (JIA) with controls, and to explore associations between these markers and VAT. We included 60 JIA patients (30 oligoarticular,30 polyarticular), aged 10-16 years, and 60 age-and sex-matched controls. VAT (g) was estimated by dual-energy x-ray absorptiometry.
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