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A peptide from Boletus griseus-Hypomyces chrysospermus protects against hypertension and associated cardiac and renal damage through modulating RAAS and intestinal microbiota.
J Food Sci
January 2025
Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming, China.
Hypertension is a major risk factor for many cardiovascular diseases, which can lead to kidney and heart disease, stroke, and premature death. Inhibiting angiotensin-converting enzyme (ACE) activity is an effective method to relieve hypertension. Previously, we screened an active peptide KYPHVF (KF6) from Boletus griseus-Hypomyces chrysospermus with excellent ACE inhibitory activity.
View Article and Find Full Text PDFCT-P39 Compared With Reference Omalizumab in Chronic Spontaneous Urticaria: Results From a Double-Blind, Randomized, Active-Controlled, Phase 3 Study.
Allergy
January 2025
St John's Institute of Dermatology, Guy's Hospital, London, UK.
Background: This study compared the therapeutic equivalence of CT-P39 (an omalizumab biosimilar) and EU-approved reference omalizumab (ref-OMA) in patients with chronic spontaneous urticaria.
Methods: This double-blind, randomized, active-controlled Phase 3 study (NCT04426890) included two 12-week treatment periods (TPs). In TP1, patients received CT-P39 300 mg, ref-OMA 300 mg, CT-P39 150 mg, or ref-OMA 150 mg.
Teratogenicity, cardiac toxicity, neurotoxicity and genotoxicity in zebrafish embryo-larvae exposed to 4-bromodiphenyl ether.
Toxicol Res (Camb)
January 2025
Department of Zoology, Guru Nanak Dev University, Amritsar 143005, India.
Polybrominated diphenyl ethers (PBDEs) have been classified as a new class of persistent organic pollutants by the United Nations Environment Programs in 2009. In environment, PBDEs can undergo the degradation process to form less brominated diphenyl ethers. In the present study, the 96 h LC value for 4-bromodiphenyl ether (BDE-3) was found to be 3.
View Article and Find Full Text PDFPlatelet-to-White Blood Cell Ratio (PWR): A Novel Prognostic Biomarker for Spontaneous Reperfusion after Primary Percutaneous Coronary Intervention.
J Saudi Heart Assoc
November 2024
Cardiology Department, Adana City Training and Research Hospital, Adana, Turkey.
Background: Spontaneous reperfusion (SR) occurring before primary percutaneous coronary intervention (PPCI) can offer additional clinical benefits to patients with ST-segment elevation myocardial infarction (STEMI). The Platelet-to-White Blood Cell Ratio (PWR) has been recognized as a prognostic indicator in various diseases. We aimed to explore the relationship between PWR and SR in patients with STEMI undergoing PPCI.
View Article and Find Full Text PDF[Research progress on clinical evaluation index of brain function after cardiopulmonary resuscitation].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
December 2024
Department of Anesthesiology, People's Hospital of Ningxia Hui Autonomous Region (the Third Medical College of Ningxia Medical University), Yinchuan 750001, Ningxia Hui Autonomous Region, China. Corresponding author: Hai Kerong, Email:
The ultimate goal of cardiac arrest-cardiopulmonary resuscitation (CA-CPR) is to reduce brain damage and promote neurological recovery. Although the return of spontaneous circulation (ROSC) has improved, the proportion of patients who survive to discharge is very low, so how to evaluate the recovery of brain function after resuscitation is particularly important in clinical work. From a clinical perspective, although early prognostic indicators are not perfect, identifying high-risk features may help clinicians determine the severity of brain injury caused by a patient's potential course of disease.
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