With the increasing prevalence of human immunodeficiency virus/AIDS patients and patients receiving chemotherapy for various malignancies, the numbers of immunosuppressed patients who present to the emergency department is on the increase. Thoracic-related emergencies in these vulnerable patients are serious and challenging to diagnose for the emergency physician, due mainly to atypical presentations, atypical pathogens, and to the often tenuous state of health of the patient. This article addresses a variety of cardiovascular, pulmonary, and esophageal emergencies that are seen specifically in immunocompromised patients presenting to the emergency department. Epidemiology, clinical presentation, investigations, prognosis, management, and evidence-based recommendations are discussed.
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http://dx.doi.org/10.1016/j.emc.2011.10.007 | DOI Listing |
mBio
January 2025
Department of Microbiology, Genetics, & Immunology, Michigan State University, East Lansing, Michigan, USA.
The emergence and global spread of carbapenem-resistant complex species present a pressing public health challenge. Carbapenem-resistant spp. cause a wide variety of infections, including septic shock fatalities in newborns and immunocompromised adults.
View Article and Find Full Text PDFCandida auris is an emerging, multidrug-resistant fungus that poses a threat in health care settings because of its persistence on surfaces and ability to cause severe infections, particularly in immunocompromised patients. First identified in Japan in 2009, C auris has since spread globally, leading to numerous outbreaks. Its unique virulence factors, such as biofilm formation and immune evasion, contribute to its resilience and resistance to eradication.
View Article and Find Full Text PDFFront Immunol
January 2025
Institute of Virology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Background: The emergence of novel SARS-CoV-2 variants challenges immunity, particularly among immunocompromised kidney transplant recipients (KTRs). To address this, vaccines have been adjusted to circulating variants. Despite intensive vaccination efforts, SARS-CoV-2 infections surged among KTRs during the Omicron wave, enabling a direct comparison of variant-specific immunity following-vaccination against Omicron BA.
View Article and Find Full Text PDFMicrobiol Spectr
January 2025
Servei de Microbiologia i Parasitologia-CDB, Hospital Clínic de Barcelona, Barcelona, Spain.
Unlabelled: is an opportunistic pathogen capable of causing severe infections in immunocompromised individuals, who often require prolonged antibiotic therapy. The emergence of carbapenemase-producing has further complicated the management of nosocomial infections, limiting therapeutic options. Cefiderocol has recently emerged as a promising antipseudomonal agent, using the bacterial iron transport system to gain entry into the cell; however, there have been reports of resistant to cefiderocol.
View Article and Find Full Text PDFChina CDC Wkly
January 2025
Fujian Provincial Center for Disease Control and Prevention, Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou City, Fujian Province, China.
What Is Known About This Topic?: Global human cases of zoonotic influenza A(H5N6) have increased significantly in recent years, primarily due to widespread circulation of clade 2.3.4.
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