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The study on cuproptosis in Alzheimer's disease based on the cuproptosis key gene .
Front Aging Neurosci
December 2024
Department of Neurology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.
Background: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and cognitive impairments. Previous studies have shown neuronal death in the brains of AD patients, but the role of cuproptosis and its associated genes in AD neurons remains unclear.
Methods: Intersection analysis was conducted using the AD transcriptome dataset GSE63060, neuron dataset GSE147528, and reported cuproptosis-related genes to identify the cuproptosis key gene highly expressed in AD.
HepG2 spheroids cultured in alginate microcapsules as a model for exploring mitochondrial and glycolytic metabolism using the Seahorse XFe24 Analyzer.
Toxicol Mech Methods
January 2025
Department of Life Sciences, of the University of Coimbra, Coimbra, Portugal.
Mitochondria are affected by chemical substances and play a critical role in drug-induced liver injury (DILI). Chemical substances can have a significant impact on various cellular processes, such as the disruption of oxidative phosphorylation, oxidative stress, and alteration of glucose metabolism. Given the consequences of these effects, it is crucial to understand the molecular pathways of chemical substances in the context of hepatotoxicity to prevent and treat DILI.
View Article and Find Full Text PDFNear-Infrared Probes Designed with Hemicyanine Fluorophores Featuring Rhodamine and 1,8-Naphthalic Derivatives for Viscosity and HSA Detection in Live Cells.
ACS Appl Bio Mater
January 2025
Department of Chemistry, Michigan Technological University, Houghton, Michigan 49931, United States.
This paper presents the development of near-infrared (NIR) fluorescent probes, and , engineered from hemicyanine dyes with 1,8-naphthalic and rhodamine derivatives for optimized photophysical properties and precise mitochondrial targeting. Probes and exhibit absorption peaks at 737 nm and low fluorescence in phosphate-buffered saline (PBS) buffer. Notably, their fluorescence intensities, peaking at 684 () and 702 nm (), increase significantly with viscosity, as demonstrated through glycerol-to-PBS ratio experiments.
View Article and Find Full Text PDFFast tracking of Hg ions in living cells, food, and environmental samples using a new mitochondria-targeted red emitting probe and its portable applications.
Environ Pollut
January 2025
Giresun University, Faculty of Engineering, Department of Environmental Engineering, Giresun 28200, Turkey.
Mercury is one of the most hazardous heavy metals and is capable of biomagnification, thereby posing severe risks to ecosystems and human health. Therefore, selective, sensitive, and rapid detection of Hg in a wide range of samples is essential. Herein, we report the synthesis of a new 2-(benzo[d]thiazol-2-yl) phenol-based fluorescent probe (PyS) and its potential as a fluorescent probe for detecting Hg ions in various real samples such as rice, garlic, shrimp, and root samples.
View Article and Find Full Text PDFElectroacupuncture attenuates ferroptosis by promoting Nrf2 nuclear translocation and activating Nrf2/SLC7A11/GPX4 pathway in ischemic stroke.
Chin Med
January 2025
Yunnan Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in Prevention and Treatment, Key Laboratory of Acupuncture and Massage for Treatment of Encephalopathy, College of Acupuncture, Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, China.
Objective: Electroacupuncture has been shown to play a neuroprotective role following ischemic stroke, but the underlying mechanism remains poorly understood. Ferroptosis has been shown to play a key role in the injury process. In the present study, we wanted to explore whether electroacupuncture could inhibit ferroptosis by promoting nuclear factor erythroid-2-related factor 2 (Nrf2) nuclear translocation.
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