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Anticancer potential of nerolidol on acute lymphoblastic leukemia cells through the interactions with the NF-κB/STAT-3 and PI3K/Akt signaling pathways.
Adv Clin Exp Med
January 2025
Department of Hematology, Rheumatology and Immunology, The First People's Hospital of Xianyang, China.
Background: Leukemia may form at any age, from newborns to the elderly, and accounts for considerable mortality worldwide.
Objectives: Nerolidol (NRD) is isolated from the aromatic florae oils and was found to have anticancer activities. However, the role of NRD in antiproliferative and apoptosis actions in acute lymphoblastic leukemia (ALL) is unclear.
Blue-LED assisted Photodegradation kinetics of rhodamine-6G dye, enhanced anticancer activity and cleavage of plasmids using Au-ZnO nanocomposite.
Heliyon
January 2025
School of Life Sciences, Department of Biochemistry, Molecular Oncology Laboratory, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.
The plasmonic metal doping on the UV-active metal oxide nanoparticle turns the resultant plasmonic metal-metal oxide (PMMO) into visible light active and upon exogenous illumination the photogenerated energetic charge carriers and the generated reactive oxygen species (ROS, e.g. ·OH and O ) authoritatively enhances its biological and catalytic activity.
View Article and Find Full Text PDFUmbelliferone inhibits proliferation and metastasis via modulating cadherin/β-catenin complex-aided cell-cell adhesion in glioblastoma cells.
Adv Clin Exp Med
January 2025
Department of Neurosurgery, The Affiliated Children's Hospital of Xi'an Jiaotong University, Xi'an Children's Hospital, China.
Background: Glioblastoma multiforme (GBM) is the most aggressive brain tumor malignancy in adults, accounting for nearly 50% of all gliomas. Current medications for GBM frequently lead to drug resistance.
Objectives: Umbelliferone (UMB) is found extensively in many plants and shows numerous pharmacological actions against inflammation, degenerative diseases and cancers.
Eupatorin modulates BCPAP in thyroid cancer cell proliferation via suppressing the NF-κB/P13K/AKT signaling pathways.
Adv Clin Exp Med
January 2025
Department of Head and Neck Oncology, Shaanxi Provincial Cancer Hospital Affiliated to Xi'an Jiaotong University, China.
Background: Thyroid carcinoma (TC), the most prevalent endocrine cancer worldwide, has become progressively more common, especially in women. Most TCs are epithelial-derived differentiated TCs, specifically papillary thyroid cancer (PTC). Although there are many therapeutic drugs available, curing TC is a difficult task.
View Article and Find Full Text PDFOptimally designed PEGylatied arabinoxylan paclitaxel nano-micelles as alternative delivery for Abraxane®: A potential targeted therapy against breast and lung cancers.
Int J Biol Macromol
December 2024
Group of Bionanotechnology and Molecular Cell Biology, Nanomedicine department, Institute of Nanoscience and Nanotechnology, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt. Electronic address:
Paclitaxel (PTX) binds to spindle microtubules and inhibits mitotic division leading to cell death. However, its wide distribution, high absorption, and less selectively, minimize its application in cancer clinics. In this study, isolated arabinoxylans were used to encapsulate PTX, and then both were covered by polyethylene glycol conjugated to folic acid (FA), to strengthen its specificity to cancerous cells.
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