AI Article Synopsis
- Epigenetic changes increase the expression of voltage-gated sodium channels (VGSCs) in cancer cells, potentially promoting behaviors that aid metastasis.
- Research indicates functional VGSCs enhance cell motility and may facilitate the spread of cancer.
- In a study using a rat model of prostate cancer, blocking VGSC activity significantly reduced lung metastases by over 40% and improved the lifespan of the subjects.
Article Abstract
Epigenetic upregulation of voltage-gated sodium channels (VGSCs) has been reported in a number of carcinoma cell lines and tissues. Furthermore, a large body of experimental evidence suggested that functional VGSC expression enhances various in vitro cell behaviours, such as directional motility, that would be involved in the metastatic cascade. However, it is not known if VGSC activity promotes metastasis in vivo. Here, using the Copenhagen rat model of prostate cancer and blocking VGSC activity in primary tumours with tetrodotoxin, we show (1) that the number of lung metastasis is reduced by >40% and (2) that lifespan is significantly improved.
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| http://dx.doi.org/10.1016/j.canlet.2012.03.036 | DOI Listing |
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