AI Article Synopsis
- The study explores how alternating exposure to morphine and saline affects the extinction of conditioned place preference (CPP) in rats, focusing on post-retrieval extinction training.
- It finds that the timing of retrieval-extinction intervals significantly impacts the success of this extinction; a 10-minute interval shows no effect, while a 3-hour interval blocks the extinction of CPP.
- The results suggest that the time between exposure sessions is crucial for the effectiveness of exposure therapy in treating addiction.
Article Abstract
Using exposure to morphine- and saline-paired sides alternatively as the extinction training procedure, we find that post-retrieval extinction training enhances or hinders the extinction of morphine-induced conditioned place preference (CPP) dependent on the retrieval-extinction training intervals. Here, we examine the influence of post-retrieval extinction training with repeated paired testing on extinction of morphine-induced CPP of rats. Our results demonstrate that paired-testing with a 10-min inter-test interval does not influence the extinction of CPP, while post-retrieval extinction training blocks the extinction of CPP with a 3-h retrieval-extinction interval. These results strongly indicate that the interval between exposure trials influences the outcome of exposure therapy in addiction treatment.
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| http://dx.doi.org/10.1016/j.neulet.2012.03.060 | DOI Listing |
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