AI Article Synopsis
- A new series of compounds featuring 1,3,4-thiadiazole and benzisoselenazolone were created using specific chemical reactions.
- Their effects on cell growth were tested in three types of cancer cells (SSMC-7721, MCF-7, and A-549).
- Some of these compounds showed promising anti-cancer properties and might be worth investigating further for their potential.
Article Abstract
A series of novel 1,3,4-thiadiazole-containing benzisoselenazolone derivatives were prepared by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted-1,3,4-thiadiazole. Their in vitro antiproliferative activities were evaluated in SSMC-7721, MCF-7 and A-549 cells. The results suggest that, in different tumor cells, some compounds have good antiproliferative activity, certain selectivity and potential value of further research.
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| http://dx.doi.org/10.1016/j.bmcl.2012.03.043 | DOI Listing |
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