AI Article Synopsis
- Four new cytochalasin derivatives were discovered from the fungus Phoma sp. found in the giant jellyfish Nemopilema nomurai, alongside the known cytochalasin B.
- The structures and stereochemistry of these compounds were determined using 1D and 2D NMR analysis, with the specific absolute configuration identified through a modified Mosher's method.
- These compounds exhibited significant cytotoxic effects on various human solid tumor cell lines, with IC(50) values ranging from 0.5 to 30 μM, while cytochalasin B showed an IC(50) of 7.9 μM specifically against HeLa cervical cancer cells.
Article Abstract
Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC(50) values in the range of 0.5-30 μM. The cytochalasin B (5) showed obvious cytotoxicity with IC(50) of 7.9 μM against HeLa human cervical carcinoma cells.
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| http://dx.doi.org/10.1016/j.bmcl.2012.03.058 | DOI Listing |
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