AI Article Synopsis
- The study analyzes clinical presentations and outcomes of children with viral hepatitis in Eastern Ontario/Western Quebec from 1998 to 2007.
- Out of 261 reviewed cases, 64 had a confirmed viral cause, predominantly hepatitis B, with positive outcomes like spontaneous seroconversion noted in 61.7% of HBV cases.
- The overall findings show that both acute and chronic hepatitis in children tend to have a mild clinical course, with excellent outcomes.
Article Abstract
Introduction. Clinical presentation of viral hepatitis ranges from mild symptoms to fulminant hepatitis. Our aim is to describe clinical presentation and outcomes of children with viral hepatitis from the Eastern Ontario/Western Quebec regions of Canada. Methods. Retrospective chart review of children diagnosed with viral hepatitis at our institution from January 1, 1998, to December 31, 2007. Results. There were 261 charts reviewed, only 64 had a confirmed viral etiology: 34 (53%) hepatitis B (HBV), 16 (25%) hepatitis C (HCV), 4 (6.3%) hepatitis A (HAV), 7 (11%) cytomegalovirus (CMV), and 3 (4.7%) Epstein-Barr virus (EBV). Children with HBV presented at a mean age of 6.4 ± 4.6 years. Spontaneous seroconversion (appearance of HBVeAb and loss of HBVeAg) occurred in 21/34 (61.7%). Children with acute hepatitis (HAV, CMV, and EBV) presented with mild abdominal pain, jaundice, and fevers. Overall outcome was excellent. Conclusion. Acute and chronic hepatitis in children has a benign course; moreover, HBV spontaneous seroconversion is common in pediatric patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317099 | PMC |
| http://dx.doi.org/10.5402/2011/182964 | DOI Listing |
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