Newcastle disease (ND) is a highly contagious viral disease and is a continuous threat to the poultry industry worldwide. In the early months of 2011, several devastating ND outbreaks occurred in Jordan affecting broilers, layers and breeders. The fusion gene of the isolated Newcastle disease virus (NDV) was partially amplified by RT-PCR, then directly sequenced. The NDV isolates were found to have the motif112RRQKRF117. This motif and a mean death time (MDT) of 46 h are indicative of the velogenic nature of these NDV isolates. Phylogenetic analysis showed that the new NDV strain belongs to the lineage 5d (Aldous et al., 2003) and is closely related to the Chinese strain SG/Liaoning/2009. NDV outbreaks in 2010 and 2011 have been noted in neighboring countries. Based on the high nucleotide similarity between our isolated NDV isolates and the Chinese NDV strain, the origin of these recent NDV isolates might be from China.
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Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China.
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Center for Emerging, Zoonotic, and Arthropod-borne Pathogens, Virginia Polytechnic Institute and State University (Virginia Tech), Blacksburg, VA, 24061, USA.
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View Article and Find Full Text PDFDetermination of immunogenicity of an inactivated ND-vaccine developed experimentally with Newcastle disease virus (Genotype VII.2) local isolates of Bangladesh.
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Article Synopsis
- Newcastle disease virus (NDV) genotype VII poses significant threats to poultry, leading to severe health issues and high mortality rates, prompting research into a locally developed inactivated vaccine.
- The inactivated ND vaccine was compared with commercial live vaccines in a study assessing different vaccination methods and doses, showing that subcutaneous administration of 1.0 ml resulted in the highest antibody levels and efficacy.
- Findings indicated that the killed-followed-killed vaccination regimen offered the best protection (100%) and sustained immunity, suggesting its effectiveness in managing ND outbreaks in poultry in Bangladesh.
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