A model study for constructing the DEF-benzoxocin ring system of menogaril and nogalamycin via a reductive Heck cyclization.

Org Lett

Department of Chemistry, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.

Published: April 2012

A novel reductive Heck cyclization approach was developed in order to construct a model DEF-benzoxocin ring system that is present in nogalamycin, menogaril, and related anthracycline antitumor antibiotics.

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Source
http://dx.doi.org/10.1021/ol300072hDOI Listing

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