Morphology of polysorbate 80 (Tween 80) micelles in aqueous dimethyl sulfoxide solutions.

J Appl Crystallogr

Faculty of Pharmaceutical Sciences, Setsunan University, 573-0101, Osaka, Japan.

Published: June 2010

The structures of micelles of the surfactant polysorbate 80 (Tween 80) in 0-50% aqueous dimethyl sulfoxide (DMSO) solutions (pH 7.2, ionic strength 2.44 mM) were investigated by means of small-angle X-ray scattering. At DMSO concentrations of 0-20%, core-shell cylinder micelles formed, and at 30-50% DMSO, core-shell discus micelles formed, that is, changing the hydrophobicity of the DMSO solvent mixture changed the micelles from core-shell cylinder micelles to core-shell discus micelles.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246828PMC
http://dx.doi.org/10.1107/S002188981000779XDOI Listing

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