The first asymmetric total synthesis and determination of the absolute configuration for the neuroactive marine macrolide palmyrolide A is described. The highlight of the synthesis is macrocyclization via trans-enamide formation catalyzed by copper(I) iodide and cesium carbonate. Comparison with the authentic spectral data confirms the synthesis of (+)-ent-palmyrolide A.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352666 | PMC |
| http://dx.doi.org/10.1021/ol300673m | DOI Listing |
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