AI Article Synopsis
- This study aimed to determine if L-carnitine could enhance pregnancy rates in men with oligoasthenozoospermia undergoing intracytoplasmic sperm injection (ICSI).
- A total of 129 men were divided into two groups: one received L-carnitine for two weeks before ICSI, while the other had ICSI without the medication, allowing for comparison of sperm quality and fertilization outcomes.
- Results showed a significant increase in sperm quality and available embryos in the L-carnitine group, suggesting that this short-term treatment could boost the success rate of ICSI.
Article Abstract
Objective: To observe the pregnancy promoting effect of L-carnitine combined with intracytoplasmic sperm injection (ICSI) in treating male infertility with oligoasthenozoospermia.
Methods: We assigned 129 patients with oligoasthenozoospermia to receive 2 weeks of oral L-carnitine followed by ICSI (medication group, n = 42) and ICSI alone (control group, n = 87). We compared the sperm concentration and motility, the percentage of grade a + b sperm, and sperm deformity before and after L-carnitine medication, as well as the rates of fertilization, cleavage, available embryo and clinical pregnancy between the two groups.
Results: The percentage of grade a + b sperm was significantly increased after L-carnitine medication as compared with the baseline ([13.5 +/- 10.7] % vs [9.6 +/- 7.2] %, P<0.05), and so was the rate of available embryo in the medication group after ICSI in comparison with that of the control group (77.50% vs 69.04%, P<0.05).
Conclusion: Short-term medication of L-carnitine can improve sperm quality and raise the success rate of ICSI.
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