Jatropha gossypifolia root bark is used in ethnomedicine for bacterial infections and cancer of the lungs. Phytochemical investigation resulted in the isolation and characterization of a potent anticancer and novel lathyrane diterpenoid compound, abiodone, with an unusual methylene group. The structure of this novel compound was established by 1D, and 2D NMR spectroscopic experiments a nd confirmed by X-ray analysis.
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Curr Drug Discov Technol
July 2024
Department of Biochemistry, Faculty of Science, Lagos State University, Ojo, Lagos State, Nigeria.
Background: Diabetes mellitus (DM) is a metabolic disorder known to impair many physiological functions via reactive oxygen species (ROS). Aldose reductase, sorbitol dehydrogenase, dipeptidyl peptidase IV, α-amylase and α-glucosidase are pharmacotherapeutic protein targets in type-2 diabetes mellitus (T2DM). Inhibitors of these enzymes constitute a new class of drugs used in the management and treatment of T2DM.
View Article and Find Full Text PDFEnviron Res
September 2023
Faculty of Mining and Geology, Technical University of Ostrava, Czech Republic.
This investigation was performed to evaluate the metal pollution and possible phytoremediation on bauxite mine surrounding farmland soil. The quality analysis results revealed that, the soil has been polluted with metals such as Al (13.25 ± 0.
View Article and Find Full Text PDFPlants (Basel)
May 2022
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbasia, Cairo 11566, Egypt.
The essential oils of , and (Euphorbiaceae) were analyzed employing GC/MS (Gas Chromatography coupled with Mass Spectrometry) analyses. A total of 95 volatile constituents were identified from and essential oils, accounting for 91.61, 90.
View Article and Find Full Text PDFPlant Dis
May 2022
NCSU, Entomology and Plant Pathology, Campus Box 7613, 2415 Gardner Hall, Raleigh , North Carolina, United States, 27695;
Stevia ( [Bertoni] Bertoni) is a perennial plant originating in Paraguay. Stevia is primarily cultivated for the production of non-caloric sweeteners. In December 2018, wilted stevia cv.
View Article and Find Full Text PDFAdv Pharmacol Pharm Sci
June 2021
Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Convulsion is a typical symptom associated with epilepsy. , a common plant in Ghana, has been used traditionally for the management of epilepsy. This study was carried out to ascertain the scientific basis for the traditional utility of for various convulsive disorders and also determine the part of the plant with the most anticonvulsant activity.
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